Mouse Models in Meningioma Research: A Systematic Review.
GEMM
meningioma
mouse model
xenograft
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
26 Jul 2021
26 Jul 2021
Historique:
received:
07
06
2021
revised:
10
07
2021
accepted:
21
07
2021
entrez:
7
8
2021
pubmed:
8
8
2021
medline:
8
8
2021
Statut:
epublish
Résumé
Meningiomas are the most frequent primitive central nervous system tumors found in adults. Mouse models of cancer have been instrumental in understanding disease mechanisms and establishing preclinical drug testing. Various mouse models of meningioma have been developed over time, evolving in light of new discoveries in our comprehension of meningioma biology and with improvements in genetic engineering techniques. We reviewed all mouse models of meningioma described in the literature, including xenograft models (orthotopic or heterotopic) with human cell lines or patient derived tumors, and genetically engineered mouse models (GEMMs). Xenograft models provided useful tools for preclinical testing of a huge range of innovative drugs and therapeutic options, which are summarized in this review. GEMMs offer the possibility of mimicking human meningiomas at the histological, anatomical, and genetic level and have been invaluable in enabling tumorigenesis mechanisms, including initiation and progression, to be dissected. Currently, researchers have a range of different mouse models that can be used depending on the scientific question to be answered.
Identifiants
pubmed: 34359639
pii: cancers13153712
doi: 10.3390/cancers13153712
pmc: PMC8345085
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Institut National de la Santé et de la Recherche Médicale
ID : Poste Accueil INSERM
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