Docetaxel Skin Exposure and Micronucleation Contributes to Skin Toxicity Caused by CPC634.
chemotherapy
docetaxel
nanoparticles
pharmacodynamics
pharmacokinetics
skin
toxicity
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
26 Jul 2021
26 Jul 2021
Historique:
received:
01
06
2021
revised:
21
07
2021
accepted:
21
07
2021
entrez:
7
8
2021
pubmed:
8
8
2021
medline:
8
8
2021
Statut:
epublish
Résumé
Docetaxel entrapped nanoparticle CPC634 is associated with dose-related skin toxicity that resembles conventional docetaxel (Cd)-related skin toxicity. This study compared the cutaneous pharmacokinetics and pharmacodynamics of docetaxel and CPC634. In this randomised cross-over study, patients with solid tumours received one cycle of CPC634 and Cd (both at 75 mg/m
Identifiants
pubmed: 34359641
pii: cancers13153741
doi: 10.3390/cancers13153741
pmc: PMC8345028
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Cristal Therapeutics
ID : NA
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