Epigenetic Reprogramming of Tumor-Associated Fibroblasts in Lung Cancer: Therapeutic Opportunities.
TGF-β
cancer-associated fibroblasts
desmoplasia
epigenetics
lung cancer
smoking
tumor stroma
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
27 Jul 2021
27 Jul 2021
Historique:
received:
21
06
2021
revised:
23
07
2021
accepted:
24
07
2021
entrez:
7
8
2021
pubmed:
8
8
2021
medline:
8
8
2021
Statut:
epublish
Résumé
Lung cancer is the leading cause of cancer-related death worldwide. The desmoplastic stroma of lung cancer and other solid tumors is rich in tumor-associated fibroblasts (TAFs) exhibiting an activated/myofibroblast-like phenotype. There is growing awareness that TAFs support key steps of tumor progression and are epigenetically reprogrammed compared to healthy fibroblasts. Although the mechanisms underlying such epigenetic reprogramming are incompletely understood, there is increasing evidence that they involve interactions with either cancer cells, pro-fibrotic cytokines such as TGF-β, the stiffening of the surrounding extracellular matrix, smoking cigarette particles and other environmental cues. These aberrant interactions elicit a global DNA hypomethylation and a selective transcriptional repression through hypermethylation of the TGF-β transcription factor
Identifiants
pubmed: 34359678
pii: cancers13153782
doi: 10.3390/cancers13153782
pmc: PMC8345093
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Ministerio de Ciencia e Innovación
ID : PID2019-110944RB-I00
Organisme : Ministerio de Ciencia e Innovación
ID : PI13/02368
Organisme : Ministerio de Ciencia e Innovación
ID : SAF2016-79527-R
Organisme : Ministerio de Ciencia e Innovación
ID : PI16/00890
Organisme : Agència de Gestió d'Ajuts Universitaris i de Recerca
ID : SGR 661
Organisme : Sociedad Española de Neumología y Cirugía Torácica
ID : SEPAR 951
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