Pathophysiological Implications of Urinary Peptides in Hepatocellular Carcinoma.
capillary electrophoresis mass spectrometry
diagnosis
hepatocellular carcinoma
prognosis
urinary peptides
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
27 Jul 2021
27 Jul 2021
Historique:
received:
17
06
2021
revised:
21
07
2021
accepted:
26
07
2021
entrez:
7
8
2021
pubmed:
8
8
2021
medline:
8
8
2021
Statut:
epublish
Résumé
Hepatocellular carcinoma (HCC) is known to be associated with protein alterations and extracellular fibrous deposition. We investigated the urinary proteomic profiles of HCC patients in this prospective cross sectional multicentre study. 195 patients were recruited from the UK (Coventry) and Germany (Hannover) between 1 January 2013 and 30 June 2019. Out of these, 57 were HCC patients with a background of liver cirrhosis (LC) and 138 were non-HCC controls; 72 patients with LC, 57 with non-cirrhotic liver disease and 9 with normal liver function. Analysis of the urine samples was performed by capillary electrophoresis (CE) coupled to mass spectrometry (MS). Peptide sequences were obtained and 31 specific peptide markers for HCC were identified and further integrated into a multivariate classification model. The peptide model demonstrated 79.5% sensitivity and 85.1% specificity (95% CI: 0.81-0.93,
Identifiants
pubmed: 34359689
pii: cancers13153786
doi: 10.3390/cancers13153786
pmc: PMC8345155
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Medical and Life Sciences Research Fund
ID : 14092020
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