Human Wnt/β-Catenin Regulates Alloimmune Signaling during Allogeneic Transplantation.
GVHD
GVT
T cells signaling
Wnt/β-catenin
cytokines
inflammation
migration
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
28 Jul 2021
28 Jul 2021
Historique:
received:
16
06
2021
revised:
16
07
2021
accepted:
19
07
2021
entrez:
7
8
2021
pubmed:
8
8
2021
medline:
8
8
2021
Statut:
epublish
Résumé
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is one of the most widely applied forms of adoptive immunotherapy for the treatment of hematological malignancies. Detrimental graft-versus-host disease (GVHD), but also beneficial graft-versus-leukemia (GVL) effects occurring after allo-HSCT are largely mediated by alloantigen-reactive donor T cells in the graft. Separating GVHD from GVL effects is a formidable challenge, and a greater understanding of donor T cell biology is required to accomplish the uncoupling of GVHD from GVL. Here, we evaluated the role of β-catenin in this process. Using a unique mouse model of transgenic overexpression of human β-catenin (
Identifiants
pubmed: 34359702
pii: cancers13153798
doi: 10.3390/cancers13153798
pmc: PMC8345079
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIAID NIH HHS
ID : K22 AI130182
Pays : United States
Organisme : NIH HHS
ID : L6 MD0010106
Pays : United States
Organisme : NIH HHS
ID : AI130182
Pays : United States
Organisme : Upstate Medical University Cancer grant
ID : 1146249-1-75632
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