Definition of Biologically Distinct Groups of Conjunctival Melanomas According to Etiological Factors and Implications for Precision Medicine.
BRAF
CTNNB1
KIT
NRAS
conjunctival melanoma
nevus
primary acquired melanocytosis
sun exposure
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
30 Jul 2021
30 Jul 2021
Historique:
received:
06
07
2021
revised:
19
07
2021
accepted:
26
07
2021
entrez:
7
8
2021
pubmed:
8
8
2021
medline:
8
8
2021
Statut:
epublish
Résumé
Conjunctival melanoma (ConjMel) is a potentially deadly ocular melanoma, originating from partially sunlight-exposed mucosa. We explored the mutational landscape of ConjMel and studied the correlation with etiological factors. We collected 47 primary ConjMel samples and performed next-generation sequencing of 400 genes. Hotspot mutations in
Identifiants
pubmed: 34359736
pii: cancers13153836
doi: 10.3390/cancers13153836
pmc: PMC8345091
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : European Commission
ID : 667787
Organisme : European Research Council
ID : ERC-ADG-2014 671262
Pays : International
Organisme : Cancer Research UK
ID : A27412 and A22902
Pays : United Kingdom
Organisme : Institut Curie
Organisme : Ligue Contre le Cancer
Organisme : Institut National de la Santé et de la Recherche Médicale
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