Ethanol-Induced Cell Damage Can Result in the Development of Oral Tumors.
ethanol
molecular alterations
mutational signatures
oral potentially malignant disorders
oral squamous cell carcinoma
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
30 Jul 2021
30 Jul 2021
Historique:
received:
15
06
2021
revised:
26
07
2021
accepted:
27
07
2021
entrez:
7
8
2021
pubmed:
8
8
2021
medline:
8
8
2021
Statut:
epublish
Résumé
Alcohol consumption is an underestimated risk factor for the development of precancerous lesions in the oral cavity. Although alcohol is a well-accepted recreational drug, 26.4% of all lip and oral cavity cancers worldwide are related to heavy drinking. Molecular mechanisms underlying this carcinogenic effect of ethanol are still under investigation. An important damaging effect comes from the first metabolite of ethanol, being acetaldehyde. Concentrations of acetaldehyde detected in the oral cavity are relatively high due to the metabolization of ethanol by oral microbes. Acetaldehyde can directly damage the DNA by the formation of mutagenic DNA adducts and interstrand crosslinks. Additionally, ethanol is known to affect epigenetic methylation and acetylation patterns, which are important regulators of gene expression. Ethanol-induced hypomethylation can activate the expression of oncogenes which subsequently can result in malignant transformation. The recent identification of ethanol-related mutational signatures emphasizes the role of acetaldehyde in alcohol-associated carcinogenesis. However, not all signatures associated with alcohol intake also relate to acetaldehyde. This finding highlights that there might be other effects of ethanol yet to be discovered.
Identifiants
pubmed: 34359747
pii: cancers13153846
doi: 10.3390/cancers13153846
pmc: PMC8345464
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Fonds Wetenschappelijk Onderzoek
ID : 11B6720N
Organisme : Fonds Wetenschappelijk Onderzoek
ID : G090618N
Organisme : Fonds Wetenschappelijk Onderzoek
ID : 1521019N
Organisme : European Research Council
ID : CoG682009
Pays : International
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