MicroRNA and Other Non-Coding RNAs in Epstein-Barr Virus-Associated Cancers.
Burkitt lymphoma
EBV
carcinogenesis
classical Hodgkin’s lymphoma
diffuse large B-cell lymphoma
gastric carcinoma
immune evasion
miRNA
microRNAome
nasopharyngeal carcinoma
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
03 Aug 2021
03 Aug 2021
Historique:
received:
31
05
2021
revised:
27
07
2021
accepted:
01
08
2021
entrez:
7
8
2021
pubmed:
8
8
2021
medline:
8
8
2021
Statut:
epublish
Résumé
EBV is a direct causative agent in around 1.5% of all cancers. The oncogenic properties of EBV are related to its ability to activate processes needed for cellular proliferation, survival, migration, and immune evasion. The EBV latency program is required for the immortalization of infected B cells and involves the expression of non-coding RNAs (ncRNAs), including viral microRNAs. These ncRNAs have different functions that contribute to virus persistence in the asymptomatic host and to the development of EBV-associated cancers. In this review, we discuss the function and potential clinical utility of EBV microRNAs and other ncRNAs in EBV-associated malignancies. This review is not intended to be comprehensive, but rather to provide examples of the importance of ncRNAs.
Identifiants
pubmed: 34359809
pii: cancers13153909
doi: 10.3390/cancers13153909
pmc: PMC8345394
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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