Adipocytes Promote Breast Cancer Cell Survival and Migration through Autophagy Activation.
adipose tissue
autophagy
breast cancer
cell communication
fatty acid
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
03 Aug 2021
03 Aug 2021
Historique:
received:
08
06
2021
revised:
15
07
2021
accepted:
29
07
2021
entrez:
7
8
2021
pubmed:
8
8
2021
medline:
8
8
2021
Statut:
epublish
Résumé
White adipose tissue interacts closely with breast cancers through the secretion of soluble factors such as cytokines, growth factors or fatty acids. However, the molecular mechanisms of these interactions and their roles in cancer progression remain poorly understood. In this study, we investigated the role of fatty acids in the cooperation between adipocytes and breast cancer cells using a co-culture model. We report that adipocytes increase autophagy in breast cancer cells through the acidification of lysosomes, leading to cancer cell survival in nutrient-deprived conditions and to cancer cell migration. Mechanistically, the disturbance of membrane phospholipid composition with a decrease in arachidonic acid content is responsible for autophagy activation in breast cancer cells induced by adipocytes. Therefore, autophagy might be a central cellular mechanism of white adipose tissue interactions with cancer cells and thus participate in cancer progression.
Identifiants
pubmed: 34359819
pii: cancers13153917
doi: 10.3390/cancers13153917
pmc: PMC8345416
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Cell Commun Signal. 2018 Jun 18;16(1):32
pubmed: 29914512
J Clin Invest. 2003 Dec;112(12):1809-20
pubmed: 14638851
Front Cell Dev Biol. 2021 Feb 05;9:629182
pubmed: 33614661
Cancer Epidemiol Biomarkers Prev. 2006 Mar;15(3):416-21
pubmed: 16537692
Med Oncol. 2013 Mar;30(1):475
pubmed: 23371253
Genes Dev. 2013 Jul 1;27(13):1447-61
pubmed: 23824538
Br J Cancer. 2020 Jan;122(1):4-22
pubmed: 31819192
Braz J Med Biol Res. 2014 Feb;47(3):192-205
pubmed: 24676492
Cancer Metastasis Rev. 2021 Mar;40(1):31-46
pubmed: 33009650
Biochim Biophys Acta. 2015 Nov;1851(11):1490-500
pubmed: 26327596
J Bioenerg Biomembr. 2006 Feb;38(1):75-82
pubmed: 16732469
Cancer Discov. 2013 Nov;3(11):1272-85
pubmed: 23965987
J Cell Physiol. 2013 Feb;228(2):457-68
pubmed: 22767159
Cell Signal. 2019 Oct;62:109336
pubmed: 31170472
Can J Biochem Physiol. 1959 Aug;37(8):911-7
pubmed: 13671378
Clin Cancer Res. 2012 Jan 15;18(2):370-9
pubmed: 22080440
Cancer Metab. 2017 Jan 13;5:1
pubmed: 28101337
Cancer Metab. 2021 Jan 7;9(1):2
pubmed: 33413672
JCI Insight. 2017 Feb 23;2(4):e87489
pubmed: 28239646
Biochimie. 2016 Nov;130:168-177
pubmed: 27473185
Nat Med. 2011 Oct 30;17(11):1498-503
pubmed: 22037646
Genes Dev. 2016 Aug 1;30(15):1704-17
pubmed: 27516533
Nature. 2000 Nov 23;408(6811):488-92
pubmed: 11100732
CA Cancer J Clin. 2017 Sep;67(5):378-397
pubmed: 28763097
FEBS J. 2018 May;285(10):1751-1766
pubmed: 29356327
J Mol Biol. 2016 Oct 27;:
pubmed: 27984040
J Pharmacol Exp Ther. 2011 Nov;339(2):487-98
pubmed: 21856859
Cell Death Dis. 2017 Feb 2;8(2):e2593
pubmed: 28151470
J Lipid Res. 2006 Feb;47(2):450-60
pubmed: 16319419
Lipids. 2020 Jul;55(4):403-412
pubmed: 32424826
Autophagy. 2007 Sep-Oct;3(5):452-60
pubmed: 17534139
EMBO J. 2015 Apr 15;34(8):1025-41
pubmed: 25586377
Cancers (Basel). 2019 Dec 13;11(12):
pubmed: 31847105
Cancer Res. 2011 Apr 1;71(7):2455-65
pubmed: 21459803
PLoS One. 2016 Jan 26;11(1):e0147148
pubmed: 26812254
Nutrients. 2020 Dec 15;12(12):
pubmed: 33333962
Cell Metab. 2018 Nov 6;28(5):689-705.e5
pubmed: 30100196
Autophagy. 2011 Nov;7(11):1348-58
pubmed: 21811093
Biochim Biophys Acta Bioenerg. 2017 Aug;1858(8):556-572
pubmed: 28167100
Nature. 2017 Jan 5;541(7635):41-45
pubmed: 27974793
Ann N Y Acad Sci. 2010 Nov;1212:E1-E19
pubmed: 21276002
Semin Cell Dev Biol. 2020 Feb;98:129-138
pubmed: 31154012
Cell Death Dis. 2013 Oct 10;4:e838
pubmed: 24113172
EMBO J. 2020 Feb 3;39(3):e102525
pubmed: 31919869
Nat Commun. 2014;5:3056
pubmed: 24445999
Cell Commun Signal. 2018 Dec 18;16(1):100
pubmed: 30563531
Oncogene. 2018 Apr;37(17):2285-2301
pubmed: 29398710