Alpha-Synuclein Preformed Fibrils Induce Cellular Senescence in Parkinson's Disease Models.

1-Methyl-4-phenylpyridinium Animals Astrocytes / metabolism Biomarkers / metabolism Brain / metabolism Cell Line Cellular Senescence Cyclin-Dependent Kinase Inhibitor p16 / metabolism Cyclin-Dependent Kinase Inhibitor p21 / metabolism Disease Models, Animal Dopaminergic Neurons / metabolism Female Glial Fibrillary Acidic Protein / metabolism HMGB1 Protein / metabolism Homeodomain Proteins / metabolism Humans Lamin Type B / metabolism Male Mice, Inbred C57BL Microglia / metabolism Parkinson Disease / pathology Postmortem Changes Rats alpha-Synuclein / metabolism
HMGB1 Lamin B1 SATB1 alpha-synuclein preformed fibrils cellular senescence microglia activation p21 reactive astrocytes

Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
05 07 2021
Historique:
received: 09 06 2021
revised: 28 06 2021
accepted: 30 06 2021
entrez: 7 8 2021
pubmed: 8 8 2021
medline: 27 10 2021
Statut: epublish

Résumé

Emerging evidence indicates that cellular senescence could be a critical inducing factor for aging-associated neurodegenerative disorders. However, the involvement of cellular senescence remains unclear in Parkinson's disease (PD). To determine this, we assessed the effects of α-synuclein preformed fibrils (α-syn PFF) or 1-methyl-4-phenylpyridinium (MPP

Identifiants

DOI: 10.3390/cells10071694 PMID: 34359864 PMC: PMC8304385
pubmed: 34359864
pii: cells10071694
doi: 10.3390/cells10071694
pmc: PMC8304385
pii:
doi:

Substances chimiques

Biomarkers 0
Cyclin-Dependent Kinase Inhibitor p16 0
Cyclin-Dependent Kinase Inhibitor p21 0
Glial Fibrillary Acidic Protein 0
HMGB1 Protein 0
Homeodomain Proteins 0
Lamin Type B 0
SATB1 protein, rat 0
alpha-Synuclein 0
1-Methyl-4-phenylpyridinium R865A5OY8J

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIH HHS
ID : 5P20GM103653
Pays : United States
Organisme : NIH HHS
ID : R01NS107404
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS107404
Pays : United States
Organisme : NINDS NIH HHS
ID : R25 NS095371
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103653
Pays : United States

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Auteurs

Dinesh Kumar Verma (DK)

Neuroscience Program, Department of Biological Sciences, Delaware State University, Dover, DE 19901, USA.
ORCID: 0000-0002-4235-9973

Bo Am Seo (BA)

Department of Neurology, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA.
Neuroregeneration & Stem Cell Program, Institute for Cell Engineering, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA.

Anurupa Ghosh (A)

Neuroscience Program, Department of Biological Sciences, Delaware State University, Dover, DE 19901, USA.

Shi-Xun Ma (SX)

Department of Neurology, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA.
Neuroregeneration & Stem Cell Program, Institute for Cell Engineering, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA.

Karina Hernandez-Quijada (K)

Neuroscience Program, Department of Biological Sciences, Delaware State University, Dover, DE 19901, USA.

Julie K Andersen (JK)

Buck Institute for Research on Aging, Novato, CA 94945, USA.

Han Seok Ko (HS)

Department of Neurology, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA.
Neuroregeneration & Stem Cell Program, Institute for Cell Engineering, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA.

Yong-Hwan Kim (YH)

Neuroscience Program, Department of Biological Sciences, Delaware State University, Dover, DE 19901, USA.
ORCID: 0000-0001-7224-0503

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Composés de pyridinium › 1-Méthyl-4-phényl-pyridinium › Alpha-Synuclein Preformed Fibrils Induce...
questionsmedicales.fr › Eucaryotes › Animaux › Alpha-Synuclein Preformed Fibrils Induce...
questionsmedicales.fr › Cellules › Névroglie › Astrocytes › Alpha-Synuclein Preformed Fibrils Induce...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Alpha-Synuclein Preformed Fibrils Induce...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Alpha-Synuclein Preformed Fibrils Induce...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Alpha-Synuclein Preformed Fibrils Induce...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Vieillissement de la cellule › Alpha-Synuclein Preformed Fibrils Induce...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines suppresseurs de tumeurs › Protéines inhibitrices des kinases cyclines-dépendantes › Inhibiteur p16 de kinase cycline-dépendante › Alpha-Synuclein Preformed Fibrils Induce...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Protéines liant le poly-adp-ribose › Inhibiteur p21 de kinase cycline-dépendante › Alpha-Synuclein Preformed Fibrils Induce...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Alpha-Synuclein Preformed Fibrils Induce...
questionsmedicales.fr › Cellules › Neurones › Neurones dopaminergiques › Alpha-Synuclein Preformed Fibrils Induce...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines de filaments intermédiaires › Protéine gliofibrillaire acide › Alpha-Synuclein Preformed Fibrils Induce...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines chromosomiques nonhistones › Protéines HMG › Protéines HMGB › Protéine HMGB1 › Alpha-Synuclein Preformed Fibrils Induce...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Protéines à homéodomaine › Alpha-Synuclein Preformed Fibrils Induce...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Alpha-Synuclein Preformed Fibrils Induce...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Protéines associées à la matrice nucléaire › Lamines › Lamine B › Alpha-Synuclein Preformed Fibrils Induce...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Alpha-Synuclein Preformed Fibrils Induce...
questionsmedicales.fr › Cellules › Névroglie › Microglie › Alpha-Synuclein Preformed Fibrils Induce...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › Alpha-Synuclein Preformed Fibrils Induce...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Mort › Cadavre › Modifications postmortem › Alpha-Synuclein Preformed Fibrils Induce...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Alpha-Synuclein Preformed Fibrils Induce...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines associées à la maladie de Parkinson › alpha-Synucléine › Alpha-Synuclein Preformed Fibrils Induce...