Keratin 7 Is a Constituent of the Keratin Network in Mouse Pancreatic Islets and Is Upregulated in Experimental Diabetes.
Krt7
MIN6
beta-cell
diabetes
islet
keratin
polarity
stress
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
21 Jul 2021
21 Jul 2021
Historique:
received:
31
05
2021
revised:
08
07
2021
accepted:
13
07
2021
entrez:
7
8
2021
pubmed:
8
8
2021
medline:
17
8
2021
Statut:
epublish
Résumé
Keratin (K) 7 is an intermediate filament protein expressed in ducts and glands of simple epithelial organs and in urothelial tissues. In the pancreas, K7 is expressed in exocrine ducts, and apico-laterally in acinar cells. Here, we report K7 expression with K8 and K18 in the endocrine islets of Langerhans in mice. K7 filament formation in islet and MIN6 β-cells is dependent on the presence and levels of K18. K18-knockout (K18
Identifiants
pubmed: 34360548
pii: ijms22157784
doi: 10.3390/ijms22157784
pmc: PMC8346022
pii:
doi:
Substances chimiques
Keratin-18
0
Keratin-7
0
Keratin-8
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Novo Nordisk Fonden
ID : NNF20OC0063889
Organisme : Novo Nordisk Fonden
ID : NNF17O0027254
Organisme : Academy of Finland
ID : 332582
Organisme : Åbo Akademi University Center of Excellence in Mechanostasis
Organisme : Medicl Supportfoundation Liv och Hälsa
Organisme : Svenska Kulturfonden
Organisme : Stiftelsen för Åbo Akademi
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