Differential Serotonin Uptake Mechanisms at the Human Maternal-Fetal Interface.
5-HT
PMAT
SERT
cord blood
feto-placental endothelial cells
organic cation transporters
placenta
platelets
trophoblasts
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
21 Jul 2021
21 Jul 2021
Historique:
received:
08
06
2021
revised:
16
07
2021
accepted:
18
07
2021
entrez:
7
8
2021
pubmed:
8
8
2021
medline:
17
8
2021
Statut:
epublish
Résumé
Serotonin (5-HT) plays an extensive role during pregnancy in regulating both the placental physiology and embryonic/fetal development. The uptake of 5-HT into cells is central to the control of local concentrations of 5-HT near its molecular targets. Here, we investigated the mechanisms of 5-HT uptake into human primary placental cells and cord blood platelets, all isolated immediately after birth. Trophoblasts and cord blood platelets showed 5-HT uptake with similar Michaelis constant (
Identifiants
pubmed: 34360573
pii: ijms22157807
doi: 10.3390/ijms22157807
pmc: PMC8346107
pii:
doi:
Substances chimiques
Serotonin Plasma Membrane Transport Proteins
0
Serotonin Receptor Agonists
0
Serotonin
333DO1RDJY
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Austrian Science Fund FWF
ID : DOC 31
Pays : Austria
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