Loss of mGluR5 in D1 Receptor-Expressing Neurons Improves Stress Coping.
D1
anxiety
mGluR5
memory
social behavior
stress
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
22 Jul 2021
22 Jul 2021
Historique:
received:
25
05
2021
revised:
11
07
2021
accepted:
19
07
2021
entrez:
7
8
2021
pubmed:
8
8
2021
medline:
17
8
2021
Statut:
epublish
Résumé
The metabotropic glutamate receptor type 5 (mGluR5) has been proposed to play a crucial role in the selection and regulation of cognitive, affective, and emotional behaviors. However, the mechanisms by which these receptors mediate these effects remain largely unexplored. Here, we studied the role of mGluR5 located in D1 receptor-expressing (D1) neurons in the manifestation of different behavioral expressions. Mice with conditional knockout (cKO) of mGluR5 in D1 neurons (mGluR5
Identifiants
pubmed: 34360592
pii: ijms22157826
doi: 10.3390/ijms22157826
pmc: PMC8346057
pii:
doi:
Substances chimiques
Grm5 protein, mouse
0
Receptor, Metabotropic Glutamate 5
0
Receptors, Dopamine D1
0
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Austrian Science Fund
ID : W12060-B10
Organisme : Austrian Science Fund
ID : W12060-B12
Organisme : Deutsche Forschungsgemeinschaft
ID : GO-Bio
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