Dysregulation of Astrocyte-Neuronal Communication in Alzheimer's Disease.
Alzheimer’s disease
amyloid plaques
calcium
glia
gliotransmission
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
23 Jul 2021
23 Jul 2021
Historique:
received:
23
06
2021
revised:
19
07
2021
accepted:
20
07
2021
entrez:
7
8
2021
pubmed:
8
8
2021
medline:
17
8
2021
Statut:
epublish
Résumé
Recent studies implicate astrocytes in Alzheimer's disease (AD); however, their role in pathogenesis is poorly understood. Astrocytes have well-established functions in supportive functions such as extracellular ionic homeostasis, structural support, and neurovascular coupling. However, emerging research on astrocytic function in the healthy brain also indicates their role in regulating synaptic plasticity and neuronal excitability via the release of neuroactive substances named gliotransmitters. Here, we review how this "active" role of astrocytes at synapses could contribute to synaptic and neuronal network dysfunction and cognitive impairment in AD.
Identifiants
pubmed: 34360652
pii: ijms22157887
doi: 10.3390/ijms22157887
pmc: PMC8346080
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDA NIH HHS
ID : R01 DA048822
Pays : United States
Organisme : NIH HHS
ID : R01NS097312
Pays : United States
Organisme : NIH HHS
ID : R01DA048822
Pays : United States
Organisme : NIH HHS
ID : R01MH119355
Pays : United States
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