Fibroblast Growth Factor 21 Response in a Preclinical Alcohol Model of Acute-on-Chronic Liver Injury.

ATP Binding Cassette Transporter, Subfamily B / physiology Acute-On-Chronic Liver Failure / metabolism Animals Bile Acids and Salts / metabolism Case-Control Studies Cholesterol 7-alpha-Hydroxylase / genetics Female Fibroblast Growth Factors / genetics Hepatocytes / metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Receptors, Cytoplasmic and Nuclear / genetics ATP-Binding Cassette Sub-Family B Member 4
ATP binding cassette subfamily B member 4 (Abcb4) knock-out mouse acute-on-chronic liver failure (ACLF) alcohol-associated liver disease (AALD) bile acid cholesterol 7α-hydroxylase (Cyp7A1) fibroblast growth factor 21 (FGF21)

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
23 Jul 2021
Historique:
received: 14 05 2021
revised: 15 07 2021
accepted: 16 07 2021
entrez: 7 8 2021
pubmed: 8 8 2021
medline: 17 8 2021
Statut: epublish

Résumé

Fibroblast growth factor (FGF) 21 has recently been shown to play a potential role in bile acid metabolism. We aimed to investigate the FGF21 response in an ethanol-induced acute-on-chronic liver injury (ACLI) model in Total RNA was extracted from wild-type (WT, C57BL/6J) and Alcohol feeding significantly induced plasma FGF21 and decreased hepatic The simultaneous upregulation of FGF21 and downregulation of

Sections du résumé

BACKGROUND AND AIMS OBJECTIVE
Fibroblast growth factor (FGF) 21 has recently been shown to play a potential role in bile acid metabolism. We aimed to investigate the FGF21 response in an ethanol-induced acute-on-chronic liver injury (ACLI) model in
METHODS METHODS
Total RNA was extracted from wild-type (WT, C57BL/6J) and
RESULTS RESULTS
Alcohol feeding significantly induced plasma FGF21 and decreased hepatic
CONCLUSIONS CONCLUSIONS
The simultaneous upregulation of FGF21 and downregulation of

Identifiants

DOI: 10.3390/ijms22157898 PMID: 34360670 PMC: PMC8348955
pubmed: 34360670
pii: ijms22157898
doi: 10.3390/ijms22157898
pmc: PMC8348955
pii:
doi:

Substances chimiques

ATP Binding Cassette Transporter, Subfamily B 0
Bile Acids and Salts 0
Receptors, Cytoplasmic and Nuclear 0
fibroblast growth factor 21 0
farnesoid X-activated receptor 0C5V0MRU6P
Fibroblast Growth Factors 62031-54-3
Cholesterol 7-alpha-Hydroxylase EC 1.14.14.23

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Bundesministerium für Bildung, Wissenschaft und Forschung
ID : LiSyM 031L0051

Références

Am J Pathol. 2016 Apr;186(4):748-60
pubmed: 26835538
Cell Metab. 2005 Oct;2(4):217-25
pubmed: 16213224
Biochim Biophys Acta Mol Basis Dis. 2019 May 1;1865(5):895-911
pubmed: 29782919
Genes Dev. 2003 Jul 1;17(13):1581-91
pubmed: 12815072
Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):14372-14377
pubmed: 27911795
Gastroenterol Res Pract. 2015;2015:717431
pubmed: 25821461
J Steroid Biochem Mol Biol. 2019 Jun;190:1-10
pubmed: 30885834
F1000Res. 2017 Nov 20;6:2029
pubmed: 29188025
Oncol Rep. 2019 Mar;41(3):1586-1602
pubmed: 30628708
Cell Rep. 2016 Sep 27;17(1):29-36
pubmed: 27681418
J Lipid Res. 2004 Jan;45(1):132-8
pubmed: 13130122
J Hepatol. 1994 Aug;21(2):235-40
pubmed: 7989715
Alcohol Clin Exp Res. 2011 May;35(5):787-93
pubmed: 21284667
Gastroenterology. 2013 Jun;144(7):1426-37, 1437.e1-9
pubmed: 23474284
Compr Physiol. 2013 Jul;3(3):1191-212
pubmed: 23897684
Bone. 2013 Aug;55(2):501-11
pubmed: 23545228
Gastroenterology. 2014 Nov;147(5):1073-83.e6
pubmed: 25083607
Mol Cell. 2000 Sep;6(3):507-15
pubmed: 11030331
J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Apr 15;957:116-22
pubmed: 24674990
Liver Int. 2017 Feb;37(2):224-231
pubmed: 27416294
Cell Metab. 2013 Feb 5;17(2):225-35
pubmed: 23395169
J Clin Exp Hepatol. 2018 Jun;8(2):162-168
pubmed: 29892179
Dig Dis. 2010;28(6):729-36
pubmed: 21525757
Biochim Biophys Acta Mol Basis Dis. 2019 Feb 1;1865(2):298-307
pubmed: 30447270
Cell Metab. 2015 Jun 2;21(6):898-904
pubmed: 26039452
PLoS One. 2013;8(1):e55615
pubmed: 23383245
Biochem Biophys Res Commun. 2014 Jan 3;443(1):68-73
pubmed: 24269813
Sci Rep. 2017 Nov 28;7(1):16482
pubmed: 29184085
Anal Biochem. 1976 May 7;72:248-54
pubmed: 942051
FASEB J. 2013 Sep;27(9):3583-93
pubmed: 23709616
Syst Biol (Stevenage). 2006 Nov;153(6):433-47
pubmed: 17186705
Biol Sex Differ. 2019 Nov 27;10(1):52
pubmed: 31775872
Acta Pharm Sin B. 2015 Mar;5(2):158-67
pubmed: 26579442
J Lipid Res. 2018 Mar;59(3):429-438
pubmed: 29295820
Cell Metab. 2007 Jun;5(6):415-25
pubmed: 17550777
Anal Biochem. 1981 Mar 15;112(1):70-5
pubmed: 7258630
PLoS One. 2013 Jul 22;8(7):e68845
pubmed: 23894352
J Endocrinol. 2018 May;237(2):139-152
pubmed: 29615519
Mol Metab. 2017 Nov;6(11):1395-1406
pubmed: 29107287
Liver Transpl. 2018 May;24(5):595-605
pubmed: 29476704
PLoS One. 2020 Dec 23;15(12):e0244356
pubmed: 33362215
J Physiol. 2019 Jul;597(14):3539-3548
pubmed: 30921473
Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3281-2
pubmed: 20167806
Diabetes. 2014 Dec;63(12):4057-63
pubmed: 25008183
Gastroenterology. 2004 Jul;127(1):261-74
pubmed: 15236191
Mol Cancer. 2012 Mar 23;11:14
pubmed: 22439738
J Intern Med. 2006 Dec;260(6):530-6
pubmed: 17116003
Cell. 1993 Nov 5;75(3):451-62
pubmed: 8106172
Hepatology. 2014 Sep;60(3):977-89
pubmed: 24590984
J Lipid Res. 2017 Aug;58(8):1548-1560
pubmed: 28536109
J Lipid Res. 1995 Sep;36(9):2059-66
pubmed: 8558093
Mol Metab. 2018 May;11:96-103
pubmed: 29627377
Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt B):2927-2937
pubmed: 29883717
J Biol Chem. 2001 Nov 9;276(45):41690-9
pubmed: 11535594
Alcohol Clin Exp Res. 1986 Oct;10(5):550-3
pubmed: 3026198
J Hepatol. 2019 Feb;70(2):237-248
pubmed: 30658725
Nat Protoc. 2013 Mar;8(3):627-37
pubmed: 23449255
J Lipid Res. 2009 Oct;50(10):1955-66
pubmed: 19346330
Hepatology. 1998 Oct;28(4):1064-72
pubmed: 9755244
Cell Metab. 2016 Feb 9;23(2):344-9
pubmed: 26724861
EBioMedicine. 2017 Feb;15:173-183
pubmed: 28041926
Nature. 2004 Sep 23;431(7007):461-6
pubmed: 15329734
Cell Metab. 2018 Jun 05;27(6):1338-1347.e4
pubmed: 29657029
Hepatol Commun. 2017 Dec 27;2(1):99-112
pubmed: 29404516
J Lipid Res. 2009 Apr;50 Suppl:S120-5
pubmed: 18815433
Int J Clin Pharmacol Ther. 2004 Jun;42(6):307-13
pubmed: 15222722
Int J Mol Sci. 2021 May 27;22(11):
pubmed: 34071962
Mol Cell. 2000 Sep;6(3):517-26
pubmed: 11030332
Hepatology. 2013 Nov;58(5):1814-23
pubmed: 23532958

Auteurs

Grigorios Christidis (G)

Department of Medicine II, Saarland University Medical Center, Saarland University, 66421 Homburg, Germany.

Ersin Karatayli (E)

Department of Medicine II, Saarland University Medical Center, Saarland University, 66421 Homburg, Germany.

Rabea A Hall (RA)

Department of Medicine II, Saarland University Medical Center, Saarland University, 66421 Homburg, Germany.

Susanne N Weber (SN)

Department of Medicine II, Saarland University Medical Center, Saarland University, 66421 Homburg, Germany.

Matthias C Reichert (MC)

Department of Medicine II, Saarland University Medical Center, Saarland University, 66421 Homburg, Germany.
ORCID: 0000-0002-8192-0575

Mathias Hohl (M)

Department of Medicine III, Saarland University Medical Center, Saarland University, 66421 Homburg, Germany.
ORCID: 0000-0001-6946-9825

Sen Qiao (S)

Department of Pharmacology and Toxicology, Saarland University Medical Center, Saarland University, 66421 Homburg, Germany.

Ulrich Boehm (U)

Department of Pharmacology and Toxicology, Saarland University Medical Center, Saarland University, 66421 Homburg, Germany.

Dieter Lütjohann (D)

Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, 53127 Bonn, Germany.
ORCID: 0000-0002-7941-8308

Frank Lammert (F)

Department of Medicine II, Saarland University Medical Center, Saarland University, 66421 Homburg, Germany.
Hannover Health Sciences Campus, Hannover Medical School (MHH), 30625 Hannover, Germany.
ORCID: 0000-0003-4450-7201

Senem Ceren Karatayli (SC)

Department of Medicine II, Saarland University Medical Center, Saarland University, 66421 Homburg, Germany.

Articles similaires

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Meal Timing and Anthropometric and Metabolic Outcomes: A Systematic Review and Meta-Analysis.

Hiu Yee Liu, Ashley A Eso, Nathan Cook et al.
1.00
Humans Meals Time Factors Female Adult

Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Transporteurs d'anions › Transporteurs d'anions organiques › Transporteurs d'anions organiques ATP-dépendants › Sous-famille B de transporteurs à cassette liant l'ATP › Fibroblast Growth Factor 21 Response in a...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Insuffisance hépatique › Défaillance hépatique › Défaillance hépatique aigüe › Insuffisance hépatique aigüe sur chronique › Fibroblast Growth Factor 21 Response in a...
questionsmedicales.fr › Eucaryotes › Animaux › Fibroblast Growth Factor 21 Response in a...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Acides et sels biliaires › Fibroblast Growth Factor 21 Response in a...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Fibroblast Growth Factor 21 Response in a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › Steroid hydroxylases › Cholesterol 7-alpha-hydroxylase › Fibroblast Growth Factor 21 Response in a...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Facteurs de croissance fibroblastique › Fibroblast Growth Factor 21 Response in a...
questionsmedicales.fr › Cellules › Cellules épithéliales › Hépatocytes › Fibroblast Growth Factor 21 Response in a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Fibroblast Growth Factor 21 Response in a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Fibroblast Growth Factor 21 Response in a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Fibroblast Growth Factor 21 Response in a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Fibroblast Growth Factor 21 Response in a...