Copresence of High-Risk Human Papillomaviruses and Epstein-Barr Virus in Colorectal Cancer: A Tissue Microarray and Molecular Study from Lebanon.
Adolescent
Adult
Aged
Aged, 80 and over
Alphapapillomavirus
/ genetics
Case-Control Studies
Child
Child, Preschool
Cohort Studies
Colorectal Neoplasms
/ epidemiology
DNA, Viral
/ genetics
Epstein-Barr Virus Infections
/ epidemiology
Female
Herpesvirus 4, Human
/ genetics
Humans
Immunohistochemistry
Lebanon
/ epidemiology
Male
Middle Aged
Papillomavirus Infections
/ epidemiology
Polymerase Chain Reaction
Prevalence
Risk Factors
Young Adult
Epstein–Barr virus
Lebanon
colorectal cancer
human papillomavirus
tumor grade
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 Jul 2021
29 Jul 2021
Historique:
received:
03
05
2021
revised:
14
06
2021
accepted:
28
06
2021
entrez:
7
8
2021
pubmed:
8
8
2021
medline:
15
9
2021
Statut:
epublish
Résumé
Colorectal cancer (CRC) is the third most common cause of cancer-related deaths worldwide. Human papillomaviruses (HPVs) and Epstein-Barr virus (EBV) have been reported to be present in different types of human cancers, including CRCs, where they can play a key role in the onset and/or progression of these cancers. Thus, we herein explored the prevalence of high-risk HPVs and EBV in a cohort of 94 CRC tissue samples and 13 colorectal normal tissues from the Lebanese population using polymerase chain reaction, immunohistochemistry, and tissue microarray methodologies. We found that high-risk HPVs are present in 64%, while EBV is present in 29% of our CRC samples. Additionally, our data showed that high-risk HPV types (16, 18, 35, 58, 51, 45, 52, 31, and 33) are the most frequent in CRC in the Lebanese cohort, respectively. Our data point out that HPVs and EBV are copresent in 28% of the samples. Thus, this study clearly suggests that high-risk HPVs and EBV are present/copresent in CRCs, where they could play an important role in colorectal carcinogenesis. Nevertheless, further investigations using a larger cohort are needed to elucidate the possible cooperation between these oncoviruses in the development of CRC.
Identifiants
pubmed: 34360884
pii: ijms22158118
doi: 10.3390/ijms22158118
pmc: PMC8347509
pii:
doi:
Substances chimiques
DNA, Viral
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Qatar University
ID : QUHI-CMED-19/20-1 and QUCG-CMED-20/21-2
Références
Proc Natl Acad Sci U S A. 1992 May 15;89(10):4442-6
pubmed: 1316608
Cancers (Basel). 2020 Mar 10;12(3):
pubmed: 32164347
World J Gastroenterol. 2012 Aug 14;18(30):4051-8
pubmed: 22912557
Am J Surg Pathol. 1994 Nov;18(11):1158-63
pubmed: 7943537
Semin Cancer Biol. 2008 Dec;18(6):381-7
pubmed: 18996483
Hum Vaccin Immunother. 2015;11(4):951-5
pubmed: 25933186
Oral Dis. 2018 May;24(4):497-508
pubmed: 28190296
Gynecol Oncol. 2001 Apr;81(1):47-52
pubmed: 11277648
Hum Genomics. 2013 Nov 27;7:23
pubmed: 24279398
J Oral Pathol Med. 2015 Jan;44(1):28-36
pubmed: 25040496
Cancer Causes Control. 2013 Jun;24(6):1207-22
pubmed: 23563998
Colorectal Dis. 2005 Sep;7(5):492-5
pubmed: 16108887
Hum Pathol. 2002 Jun;33(6):608-14
pubmed: 12152159
Mol Med Rep. 2013 Jan;7(1):89-92
pubmed: 23128841
Pathogens. 2020 Apr 20;9(4):
pubmed: 32325943
Front Oncol. 2021 Mar 12;11:630408
pubmed: 33777781
Int J Cancer. 2007 Oct 15;121(8):1813-20
pubmed: 17546592
EMBO J. 1992 Jul;11(7):2425-31
pubmed: 1321031
Asian J Androl. 2019 Jul-Aug;21(4):375-380
pubmed: 31134917
Asian Pac J Cancer Prev. 2015;16(17):7883-7
pubmed: 26625815
Cancer Epidemiol Biomarkers Prev. 2015 Jul;24(7):1024-31
pubmed: 25976416
Infect Agent Cancer. 2014 Jun 03;9:18
pubmed: 24936208
Front Oncol. 2018 May 01;8:111
pubmed: 29765906
Cancer. 2004 Jul 15;101(2):270-80
pubmed: 15241823
Med Hypotheses. 2009 Aug;73(2):184-6
pubmed: 19361933
Eur J Gynaecol Oncol. 2002;23(5):429-32
pubmed: 12440818
Ann Surg Oncol. 2018 Jun;25(6):1454-1455
pubmed: 29616422
J Clin Diagn Res. 2017 Jun;11(6):XC10-XC13
pubmed: 28764278
Eur J Surg Oncol. 2007 Jun;33(5):569-74
pubmed: 17321098
Cancer Cell Int. 2020 Aug 3;20:361
pubmed: 32774155
Clin Cancer Res. 2004 Feb 1;10(3):803-21
pubmed: 14871955
Transl Oncol. 2018 Jun;11(3):593-598
pubmed: 29547758
Prostate. 2013 Feb 15;73(3):236-41
pubmed: 22851253
J Pathol. 2003 Oct;201(2):312-8
pubmed: 14517849
Cell Cycle. 2007 Aug 15;6(16):2038-42
pubmed: 17721085
Kobe J Med Sci. 2004 Jan;50(1-2):9-19
pubmed: 15342967
Front Oncol. 2018 Jul 02;8:250
pubmed: 30035100
J Natl Cancer Inst. 2006 Mar 1;98(5):303-15
pubmed: 16507827
J Clin Microbiol. 2001 Nov;39(11):4152-4
pubmed: 11682546
Ai Zheng. 2006 Nov;25(11):1356-60
pubmed: 17094901
Crit Rev Oncol Hematol. 2003 Jan;45(1):1-36
pubmed: 12482570
Cancer Epidemiol Biomarkers Prev. 2008 Jul;17(7):1611-22
pubmed: 18628412
Int J Cancer. 2009 May 15;124(10):2501-3
pubmed: 19170205
Nat Rev Cancer. 2004 Oct;4(10):757-68
pubmed: 15510157
Iran Biomed J. 2016 Nov;20(5):302-6
pubmed: 26975327
Int J Cancer. 2019 Apr 15;144(8):1941-1953
pubmed: 30350310
Rev Med Virol. 2014 May;24(3):142-53
pubmed: 24339346
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Jan;79(1):57-63
pubmed: 7614163
Pol J Pathol. 2015 Jun;66(2):154-60
pubmed: 26247529
Oncol Rep. 2004 Nov;12(5):1093-8
pubmed: 15492798
Hum Vaccin Immunother. 2020 Oct 2;16(10):2403-2407
pubmed: 32186955
Front Oncol. 2018 Apr 20;8:123
pubmed: 29732319
Saudi Med J. 2016 Mar;37(3):256-61
pubmed: 26905346
Cell Adh Migr. 2015;9(5):392-3
pubmed: 26177717
Mol Cell Biol. 1993 Feb;13(2):775-84
pubmed: 8380895
Tumour Biol. 2011 Aug;32(4):653-9
pubmed: 21625944
Infect Agent Cancer. 2017 Oct 16;12:55
pubmed: 29075317
Colorectal Dis. 2011 Aug;13(8):865-71
pubmed: 20528894
J Exp Clin Cancer Res. 2004 Dec;23(4):561-6
pubmed: 15743024
Anticancer Res. 2015 Mar;35(3):1657-61
pubmed: 25750324
Oncol Rep. 2015 Sep;34(3):1087-96
pubmed: 26151224
Cell Cycle. 2009 Jun 15;8(12):1964-5
pubmed: 19411835
Int J Colorectal Dis. 1998;13(2):108-11
pubmed: 9638498
J Med Virol. 2001 Aug;64(4):513-8
pubmed: 11468737
Hum Pathol. 2001 Mar;32(3):297-301
pubmed: 11274639
Clin Cancer Res. 2005 Apr 15;11(8):2862-7
pubmed: 15837733
Turk J Med Sci. 2014;44(3):501-3
pubmed: 25558656
Pathogens. 2020 Jun 08;9(6):
pubmed: 32521661
Acta Virol. 1988 Jul;32(4):303-8
pubmed: 2903634
J Gastrointest Oncol. 2015 Jun;6(3):287-95
pubmed: 26029456
Am J Transplant. 2010 Sep;10(9):2043-50
pubmed: 20883538
J Cancer. 2013;4(3):227-40
pubmed: 23459622
J BUON. 2009 Jul-Sep;14(3):495-9
pubmed: 19810144
Hum Vaccin Immunother. 2014;10(7):1812-21
pubmed: 25424787
Hum Vaccin Immunother. 2017 Jul 3;13(7):1573-1578
pubmed: 28350509
Anticancer Res. 2012 Feb;32(2):571-80
pubmed: 22287747
Pathol Res Pract. 2010 Dec 15;206(12):846-50
pubmed: 20846793
Clin Microbiol Infect. 2010 Mar;16(3):262-6
pubmed: 19438642
World J Gastroenterol. 2003 Nov;9(11):2464-8
pubmed: 14606077
J Surg Oncol. 1992 Sep;51(1):5-7
pubmed: 1325576
Hum Vaccin Immunother. 2021 Apr 3;17(4):982-989
pubmed: 33006291
Mem Inst Oswaldo Cruz. 2016 Dec;111(12):731-736
pubmed: 27812599
J Exp Med. 1965 May 1;121:761-70
pubmed: 14278230
Front Oncol. 2020 Aug 20;10:1016
pubmed: 32974123
Front Oncol. 2018 Apr 17;8:113
pubmed: 29719817
Arch Pathol Lab Med. 2000 Jul;124(7):979-94
pubmed: 10888773
J Gen Virol. 2015 Jan;96(Pt 1):206-209
pubmed: 25296558
Chin J Cancer. 2016 Jan 22;35:16
pubmed: 26801987
Hum Vaccin Immunother. 2016 Jul 2;12(7):1936-9
pubmed: 27082145
Virus Res. 2017 Mar 2;231:139-147
pubmed: 27826043
Hum Vaccin Immunother. 2019;15(3):603-610
pubmed: 30380978
Cancer Res. 2002 Sep 1;62(17):4876-8
pubmed: 12208733
Br J Cancer. 2008 Aug 5;99(3):404-7
pubmed: 18648363
Gastroenterol Res Pract. 2016;2016:7896716
pubmed: 26904111
Infect Agent Cancer. 2020 Jan 6;15:1
pubmed: 31921331
Med Oncol. 2011 Mar;28(1):127-32
pubmed: 20082157
BMC Cancer. 2006 May 04;6:115
pubmed: 16672071
Asian Pac J Cancer Prev. 2018 Jan 27;19(1):193-198
pubmed: 29373913