The Role of Caspase-12 in Retinal Bystander Cell Death and Innate Immune Responses against MCMV Retinitis.
Animals
Apoptosis
/ genetics
Caspase 12
/ deficiency
Cytomegalovirus Retinitis
/ enzymology
Female
Immunity, Innate
/ genetics
In Situ Nick-End Labeling
/ methods
Interferons
/ biosynthesis
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Knockout
Muromegalovirus
/ physiology
Retina
/ enzymology
Retinal Neurons
/ enzymology
Signal Transduction
/ genetics
Tumor Suppressor Protein p53
/ metabolism
Virus Replication
/ genetics
caspase-12
caspase-3
interferons
murine cytomegalovirus
p53
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 Jul 2021
29 Jul 2021
Historique:
received:
13
05
2021
revised:
29
06
2021
accepted:
04
07
2021
entrez:
7
8
2021
pubmed:
8
8
2021
medline:
18
9
2021
Statut:
epublish
Résumé
(1) Background: caspase-12 is activated during cytomegalovirus retinitis, although its role is presently unclear. (2) Methods:
Identifiants
pubmed: 34360899
pii: ijms22158135
doi: 10.3390/ijms22158135
pmc: PMC8348425
pii:
doi:
Substances chimiques
Trp53 protein, mouse
0
Tumor Suppressor Protein p53
0
Interferons
9008-11-1
Casp12 protein, mouse
EC 3.4.22.-
Caspase 12
EC 3.4.22.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NEI NIH HHS
ID : P30 EY031631
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY026642
Pays : United States
Organisme : NIH HHS
ID : RO1 EY026642
Pays : United States
Organisme : NIH HHS
ID : P30 EY031631
Pays : United States
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