Gene Expression Profile of Human Mesenchymal Stromal Cells Exposed to Hypoxic and Pseudohypoxic Preconditioning-An Analysis by RNA Sequencing.
HIF-1α
MSCs
PHDs inhibitor
RNA-Seq
Vadadustat
hypoxic priming
mesenchymal stem cells
transcriptional regulation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 Jul 2021
29 Jul 2021
Historique:
received:
30
06
2021
revised:
24
07
2021
accepted:
26
07
2021
entrez:
7
8
2021
pubmed:
8
8
2021
medline:
14
9
2021
Statut:
epublish
Résumé
Mesenchymal stromal cell (MSC) therapy is making its way into clinical practice, accompanied by research into strategies improving their therapeutic potential. Preconditioning MSCs with hypoxia-inducible factors-α (HIFα) stabilizers is an alternative to hypoxic priming, but there remains insufficient data evaluating its transcriptomic effect. Herein, we determined the gene expression profile of 6 human bone marrow-derived MSCs preconditioned for 6 h in 2% O
Identifiants
pubmed: 34360925
pii: ijms22158160
doi: 10.3390/ijms22158160
pmc: PMC8348678
pii:
doi:
Substances chimiques
Picolinic Acids
0
vadadustat
0
Glycine
TE7660XO1C
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Narodowe Centrum Nauki
ID : 2017/25/B/NZ6/01380
Références
J Transl Med. 2018 Aug 10;16(1):222
pubmed: 30097061
Surg Oncol. 2007 Dec;16 Suppl 1:S25-7
pubmed: 18023174
Stem Cells Dev. 2017 Jul 1;26(13):973-985
pubmed: 28520516
Transplantation. 2007 Jul 27;84(2):231-7
pubmed: 17667815
FASEB J. 2020 Jun;34(6):8250-8264
pubmed: 32333618
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Nucleic Acids Res. 2019 Jan 8;47(D1):D607-D613
pubmed: 30476243
Stem Cells. 2013 Sep;31(9):1902-9
pubmed: 23744828
Nat Methods. 2017 Apr;14(4):417-419
pubmed: 28263959
Int J Mol Sci. 2019 Mar 08;20(5):
pubmed: 30857245
Stem Cell Res Ther. 2020 Mar 20;11(1):130
pubmed: 32197638
FEBS J. 2010 May;277(10):2230-7
pubmed: 20402763
Acta Biomater. 2020 Feb;103:196-212
pubmed: 31857259
Pflugers Arch. 2005 Sep;450(6):363-71
pubmed: 16007431
Stem Cells. 2008 Aug;26(8):2173-82
pubmed: 18511601
Stem Cell Res Ther. 2015 May 20;6:97
pubmed: 25986930
Cells. 2020 Nov 01;9(11):
pubmed: 33139632
Wellcome Open Res. 2019 Jan 29;4:17
pubmed: 30801039
Genome Biol. 2014;15(12):550
pubmed: 25516281
Stem Cell Res Ther. 2020 Aug 8;11(1):345
pubmed: 32771052
Cell Death Differ. 2012 May;19(5):743-55
pubmed: 22139129
Stem Cells. 2015 Jun;33(6):1818-28
pubmed: 25702874
Nat Rev Immunol. 2018 Dec;18(12):745-758
pubmed: 30242265
J Immunol. 2016 Jul 1;197(1):296-302
pubmed: 27259858
Nat Biotechnol. 2019 Aug;37(8):907-915
pubmed: 31375807
J Cell Physiol. 2010 Apr;223(1):27-35
pubmed: 20020504
Nucleic Acids Res. 2019 Jul 2;47(W1):W191-W198
pubmed: 31066453
J Biol Chem. 2016 Sep 23;291(39):20661-73
pubmed: 27502280
Stem Cell Res Ther. 2018 Sep 21;9(1):239
pubmed: 30241573
Int J Mol Sci. 2017 Jun 21;18(6):
pubmed: 28635661
N Engl J Med. 2020 Jul 2;383(1):e3
pubmed: 32609999
Biomedicines. 2021 Apr 24;9(5):
pubmed: 33923349
J R Soc Interface. 2013 Dec 18;11(92):20130950
pubmed: 24352673
Expert Opin Biol Ther. 2013 Jul;13(7):959-72
pubmed: 23536977
Biomedicines. 2020 Jan 09;8(1):
pubmed: 31936636
Genome Res. 2003 Nov;13(11):2498-504
pubmed: 14597658
F1000Res. 2015 Dec 30;4:1521
pubmed: 26925227
Cytotherapy. 2006;8(4):315-7
pubmed: 16923606
Nat Protoc. 2019 Feb;14(2):482-517
pubmed: 30664679
Sci Adv. 2020 Jul 22;6(30):eaba6884
pubmed: 32832666
Front Med (Lausanne). 2018 May 04;5:131
pubmed: 29780805
Stem Cells. 2017 Mar;35(3):766-776
pubmed: 27671847
NPJ Regen Med. 2019 Dec 2;4:22
pubmed: 31815001
J Mol Med (Berl). 2014 Aug;92(8):825-36
pubmed: 24916472
Front Cell Dev Biol. 2020 Sep 25;8:576176
pubmed: 33102483
Biomed Res Int. 2014;2014:462472
pubmed: 25133162
Stem Cell Res Ther. 2016 Dec 1;7(1):179
pubmed: 27906055
Clin Exp Immunol. 2005 Oct;142(1):12-20
pubmed: 16178851