Coxsackievirus B4 Transplacental Infection Severely Disturbs Central Tolerogenic Mechanisms in the Fetal Thymus.
Coxsackievirus B4
autoantigens
autoimmunity
central self-tolerance
in utero infection
thymic epithelial cells
thymus
transcription factors
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
19 Jul 2021
19 Jul 2021
Historique:
received:
09
06
2021
revised:
10
07
2021
accepted:
16
07
2021
entrez:
7
8
2021
pubmed:
8
8
2021
medline:
8
8
2021
Statut:
epublish
Résumé
Thymus plays a fundamental role in central tolerance establishment, especially during fetal life, through the generation of self-tolerant T cells. This process consists in T cells education by presenting them tissue-restricted autoantigens promiscuously expressed by thymic epithelial cells (TECs), thus preventing autoimmunity. Thymus infection by Coxsackievirus B (CV-B) during fetal life is supposed to disturb thymic functions and, hence, to be an inducing or accelerating factor in the genesis of autoimmunity. To further investigate this hypothesis, in our current study, we analyzed thymic expression of autoantigens, at the transcriptional and protein level, following in utero infection by CV-B4. mRNA expression levels of
Identifiants
pubmed: 34361972
pii: microorganisms9071537
doi: 10.3390/microorganisms9071537
pmc: PMC8303261
pii:
doi:
Types de publication
Journal Article
Langues
eng
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