Molecular Pathogenesis of Psoriasis and Biomarkers Reflecting Disease Activity.
Th17 cells
adipokines
fatty acid-binding protein
glycoproteins
inflammatory skin disease
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
21 Jul 2021
21 Jul 2021
Historique:
received:
12
06
2021
revised:
18
07
2021
accepted:
19
07
2021
entrez:
7
8
2021
pubmed:
8
8
2021
medline:
8
8
2021
Statut:
epublish
Résumé
Psoriasis is a chronic inflammatory skin disease induced by multifactorial causes and is characterized by bothersome, scaly reddish plaques, especially on frequently chafed body parts, such as extensor sites of the extremities. The latest advances in molecular-targeted therapies using biologics or small-molecule inhibitors help to sufficiently treat even the most severe psoriatic symptoms and the extra cutaneous comorbidities of psoriatic arthritis. The excellent clinical effects of these therapies provide a deeper understanding of the impaired quality of life caused by this disease and the detailed molecular mechanism in which the interleukin (IL)-23/IL-17 axis plays an essential role. To establish standardized therapeutic strategies, biomarkers that define deep remission are indispensable. Several molecules, such as cytokines, chemokines, antimicrobial peptides, and proteinase inhibitors, have been recognized as potent biomarker candidates. In particular, blood protein markers that are repeatedly measurable can be extremely useful in daily clinical practice. Herein, we summarize the molecular mechanism of psoriasis, and we describe the functions and induction mechanisms of these biomarker candidates.
Identifiants
pubmed: 34361983
pii: jcm10153199
doi: 10.3390/jcm10153199
pmc: PMC8346978
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
J Dermatol. 2021 Jun;48(6):761-777
pubmed: 33404109
Trends Immunol. 2009 Mar;30(3):131-41
pubmed: 19217824
J Allergy Clin Immunol. 2017 Mar;139(3):923-932.e8
pubmed: 27502297
Nutrition. 2020 Jun;74:110757
pubmed: 32222582
Int J Oncol. 2012 Nov;41(5):1577-86
pubmed: 22922995
Atherosclerosis. 2016 Jan;244:211-5
pubmed: 26687466
Nature. 2017 Mar 9;543(7644):252-256
pubmed: 28219080
Arch Dermatol Res. 2012 Aug;304(6):465-9
pubmed: 22426986
J Dermatol Sci. 2012 Jan;65(1):4-11
pubmed: 22177422
BMC Dermatol. 2020 Dec 10;20(1):22
pubmed: 33302933
J Dermatol Sci. 2021 Mar;101(3):185-193
pubmed: 33495058
J Dermatol. 2014 Aug;41(8):686-9
pubmed: 25040258
J Invest Dermatol. 2011 Mar;131(3):604-12
pubmed: 21068754
J Eur Acad Dermatol Venereol. 2011 Oct;25(10):1187-93
pubmed: 21241371
N Engl J Med. 2009 Jul 30;361(5):496-509
pubmed: 19641206
J Clin Invest. 2001 May;107(9):1173-81
pubmed: 11342581
Science. 2020 May 1;368(6490):
pubmed: 32355003
Front Immunol. 2019 Jul 31;10:1807
pubmed: 31417571
J Exp Med. 2016 Sep 19;213(10):2147-66
pubmed: 27551155
Arch Dermatol Res. 2017 Jul;309(5):371-380
pubmed: 28585093
Dermatol Ther. 2021 Jan;34(1):e14606
pubmed: 33249724
Cell Signal. 2013 Jul;25(7):1567-73
pubmed: 23562456
Trends Pharmacol Sci. 2015 Jul;36(7):461-70
pubmed: 26022934
Nat Rev Endocrinol. 2015 Oct;11(10):592-605
pubmed: 26260145
Ann Rheum Dis. 2019 Sep;78(9):1167-1178
pubmed: 31278139
JAMA Dermatol. 2013 Jul;149(7):795-801
pubmed: 23752669
Cell Signal. 2020 Nov;75:109773
pubmed: 32898612
Cytokine Growth Factor Rev. 2003 Oct;14(5):409-26
pubmed: 12948524
Front Immunol. 2020 Jan 15;10:3096
pubmed: 32010143
Nat Clin Pract Cardiovasc Med. 2009 Jan;6(1):27-35
pubmed: 19029992
Cold Spring Harb Perspect Biol. 2018 Apr 2;10(4):
pubmed: 28620097
J Invest Dermatol. 2013 Jan;133(1):164-71
pubmed: 22895364
J Dermatol Sci. 1997 Nov;16(1):17-22
pubmed: 9438903
J Dermatol. 2020 May;47(5):452-457
pubmed: 32173900
Scand J Immunol. 2020 Mar;91(3):e12846
pubmed: 31692008
Sci Rep. 2019 Mar 26;9(1):5211
pubmed: 30914699
J Invest Dermatol. 2011 Mar;131(3):677-87
pubmed: 21085185
Br J Dermatol. 2018 Aug;179(2):273-281
pubmed: 29432655
J Eur Acad Dermatol Venereol. 2015 Oct;29(10):1995-2001
pubmed: 25823684
Dermatology. 2016;232(6):633-639
pubmed: 28226326
Arthritis Rheum. 2008 Jul 15;59(7):996-1001
pubmed: 18576309
Exp Dermatol. 2011 Feb;20(2):81-7
pubmed: 21255085
Immunity. 2009 Jan 16;30(1):108-19
pubmed: 19144317
Hum Genomics. 2011 Mar;5(3):170-91
pubmed: 21504868
Immunol Res. 2018 Jun;66(3):305-312
pubmed: 29749583
Nature. 2013 Jul 18;499(7458):306-11
pubmed: 23868260
J Dermatol. 2017 Oct;44(10):1112-1121
pubmed: 28493493
Clin Exp Dermatol. 2018 Oct;43(7):790-797
pubmed: 29748971
J Dermatol Sci. 2017 May;86(2):170-174
pubmed: 28179066
Int J Mol Sci. 2019 Jul 05;20(13):
pubmed: 31284527
J Dermatol Sci. 2016 Jun;82(3):175-88
pubmed: 26976687
Br J Dermatol. 2014 Mar;170(3):634-42
pubmed: 24641585
J Autoimmun. 2015 Nov;64:66-73
pubmed: 26215033
Acta Derm Venereol. 1997 Jan;77(1):14-9
pubmed: 9059669
Cardiovasc Res. 2019 Mar 15;115(4):721-728
pubmed: 30721933
Front Immunol. 2019 Oct 09;10:2376
pubmed: 31649677
Front Oncol. 2018 Mar 21;8:78
pubmed: 29619344
JAMA. 2016 Mar 15;315(11):1107-8
pubmed: 26978201
J Dermatol Sci. 2003 May;31(3):179-87
pubmed: 12727021
Am J Respir Cell Mol Biol. 2010 Jun;42(6):635-43
pubmed: 20395631
Lipids. 2017 Jan;52(1):51-60
pubmed: 27864793
J Invest Dermatol. 2019 Dec;139(12):2437-2446.e1
pubmed: 31207232
J Invest Dermatol. 1992 Sep;99(3):299-305
pubmed: 1512466
J Eur Acad Dermatol Venereol. 2010 Dec;24(12):1386-94
pubmed: 20337818
J Clin Med. 2019 Jul 12;8(7):
pubmed: 31336842
J Dermatol. 2018 Jun;45(6):710-714
pubmed: 29655215
Exp Dermatol. 2006 Nov;15(11):900-3
pubmed: 17002687
J Invest Dermatol. 2016 Jan;136(1):161-172
pubmed: 26763436
J Dermatolog Treat. 2020 Aug;31(5):531-534
pubmed: 31179792
Br J Dermatol. 2016 Jun;174(6):1327-36
pubmed: 26822223
Circulation. 2007 Sep 11;116(11):1234-41
pubmed: 17709633
Clin Dermatol. 2007 Nov-Dec;25(6):616-24
pubmed: 18021900
Blood. 2013 Nov 7;122(19):3263-7
pubmed: 24065242
Immunity. 2015 Oct 20;43(4):727-38
pubmed: 26431948
Front Immunol. 2018 Apr 06;9:700
pubmed: 29681905
Lancet. 2015 Sep 5;386(9997):983-94
pubmed: 26025581
Am J Clin Nutr. 2016 Aug;104(2):259-65
pubmed: 27334236
Exp Dermatol. 2011 Apr;20(4):303-7
pubmed: 21410760
J Dermatol Sci. 2019 Apr;94(1):244-251
pubmed: 31010609
Br J Dermatol. 2020 Oct;183(4):664-672
pubmed: 32173852
Immunity. 2017 Dec 19;47(6):1012-1014
pubmed: 29262342
Biochem J. 2020 Mar 27;477(6):1089-1107
pubmed: 32202638
J Am Acad Dermatol. 2014 Jul;71(1):133-40
pubmed: 24709272
J Dermatol. 2013 Oct;40(10):805-12
pubmed: 23915382
J Biol Chem. 2010 Oct 22;285(43):32679-32683
pubmed: 20716527
J Invest Dermatol. 2011 Sep;131(9):1853-60
pubmed: 21654831
Atherosclerosis. 2014 Mar;233(1):104-12
pubmed: 24529130
J Eur Acad Dermatol Venereol. 2010 Sep;24(9):1035-9
pubmed: 20136680
Front Immunol. 2018 Sep 25;9:2226
pubmed: 30319661
J Dermatol. 2020 Oct;47(10):1149-1156
pubmed: 32677127
Nat Commun. 2018 Apr 12;9(1):1420
pubmed: 29650963
J Dermatol Sci. 2015 Sep;79(3):214-21
pubmed: 26055798
Cancer Cell. 2016 Jul 11;30(1):161-175
pubmed: 27411590
J Allergy Clin Immunol. 2004 May;113(5):940-8
pubmed: 15131578
J Invest Dermatol. 2009 Sep;129(9):2175-83
pubmed: 19295614
J Dermatol. 2016 Sep;43(9):1011-7
pubmed: 26919410
J Dermatol Sci. 2006 Aug;43(2):75-84
pubmed: 16859899
J Dermatol. 2019 Dec;46(12):e468-e469
pubmed: 31502309
J Am Acad Dermatol. 2019 May;80(5):1344-1352
pubmed: 30716404
Oncotarget. 2017 Nov 1;9(1):1266-1278
pubmed: 29416693
Br J Dermatol. 2020 Jun;182(6):1502-1503
pubmed: 31853957
Front Immunol. 2019 Jun 20;10:1412
pubmed: 31281320
J Invest Dermatol. 2002 Jul;119(1):50-5
pubmed: 12164924
Br J Dermatol. 2019 Aug;181(2):379-380
pubmed: 30695115
Clin Exp Med. 2019 Feb;19(1):37-45
pubmed: 30478648
Proc Natl Acad Sci U S A. 2004 Dec 21;101(51):17795-800
pubmed: 15596719
J Am Acad Dermatol. 2014 Oct;71(4):642-8
pubmed: 25043845
Sci Immunol. 2018 Oct 26;3(28):
pubmed: 30366940
Trends Immunol. 2017 May;38(5):310-322
pubmed: 28254169
JAMA. 2020 May 19;323(19):1945-1960
pubmed: 32427307
J Allergy Clin Immunol. 2001 Mar;107(3):535-41
pubmed: 11240957
Int J Mol Sci. 2020 Sep 16;21(18):
pubmed: 32947991
Immunity. 2015 Oct 20;43(4):739-50
pubmed: 26431947
Biochem Pharmacol. 2012 Mar 15;83(6):695-704
pubmed: 22100985
Br J Dermatol. 2001 Jun;144(6):1105-13
pubmed: 11422028
J Allergy Clin Immunol. 2005 May;115(5):911-9; quiz 920
pubmed: 15867843
Ann Clin Lab Sci. 2015 Fall;45(5):556-61
pubmed: 26586708
Eur J Immunol. 2017 Apr;47(4):607-614
pubmed: 28295238
Acta Derm Venereol. 2012 Jan;92(1):67-72
pubmed: 21879243
Nat Commun. 2015 Jul 15;6:7687
pubmed: 26173479
J Eur Acad Dermatol Venereol. 2015 Apr;29(4):682-8
pubmed: 25087779
J Dermatol. 2020 Feb;47(2):104-113
pubmed: 31833093
Acta Derm Venereol. 2016 Mar;96(3):386-7
pubmed: 26524325
Nat Med. 2015 Jul;21(7):719-29
pubmed: 26121196
Nat Rev Immunol. 2014 Dec;14(12):783-95
pubmed: 25421700
Autoimmun Rev. 2014 Sep;13(9):981-1000
pubmed: 25092612
Trends Endocrinol Metab. 2002 Jan-Feb;13(1):18-23
pubmed: 11750858
Nat Rev Rheumatol. 2016 Jan;12(1):49-62
pubmed: 26656660
Br J Dermatol. 2019 Nov;181(5):946-953
pubmed: 30729517
J Invest Dermatol. 2012 Mar;132(3 Pt 2):887-95
pubmed: 22158560
Blood. 2008 Sep 15;112(6):2340-52
pubmed: 18617638
Sci Immunol. 2019 Jun 7;4(36):
pubmed: 31175175
J Invest Dermatol. 2001 Jul;117(1):106-11
pubmed: 11442756
J Allergy Clin Immunol. 2018 Sep;142(3):1010-1013.e6
pubmed: 29936103
Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):12460-12465
pubmed: 29109267
Int J Dermatol. 2019 Feb;58(2):205-209
pubmed: 30198145
Arch Dermatol Res. 2013 Mar;305(2):113-6
pubmed: 23291856
Nat Rev Immunol. 2011 Feb;11(2):85-97
pubmed: 21252989
J Dermatol. 2018 Mar;45(3):264-272
pubmed: 29226422
J Invest Dermatol. 2015 Apr;135(4):1025-1032
pubmed: 25525775
J Autoimmun. 2017 Jun;80:28-38
pubmed: 28196704
Dermatol Ther (Heidelb). 2020 Dec;10(6):1397-1404
pubmed: 32910360
Front Immunol. 2019 May 24;10:1162
pubmed: 31191535
Clin Exp Dermatol. 2018 Apr;43(3):262-267
pubmed: 29333662
Curr Opin Immunol. 2008 Aug;20(4):401-7
pubmed: 18611439
J Eur Acad Dermatol Venereol. 2020 Aug;34(8):1695-1706
pubmed: 32022950
Biochim Biophys Acta Mol Cell Res. 2020 Jun;1867(6):118677
pubmed: 32057918
J Invest Dermatol. 2019 Jun;139(6):1329-1338.e7
pubmed: 30776434
Lab Invest. 2001 Mar;81(3):335-47
pubmed: 11310827
Sci Rep. 2017 Nov 15;7(1):15631
pubmed: 29142248
Immunity. 2012 May 25;36(5):705-16
pubmed: 22633458
Biochem Pharmacol. 2019 Jul;165:196-206
pubmed: 30910694
J Dermatol Sci. 2011 Oct;64(1):75-7
pubmed: 21782391
J Am Acad Dermatol. 2014 Apr;70(4):774-779
pubmed: 24406087
J Invest Dermatol. 1994 Jul;103(1):88-91
pubmed: 8027586
Immunity. 2017 Dec 19;47(6):1154-1168.e6
pubmed: 29221731
Front Immunol. 2018 Nov 28;9:2746
pubmed: 30555460
Exp Dermatol. 2013 Apr;22(4):255-61
pubmed: 23528210
FEBS J. 2018 Aug;285(16):2944-2971
pubmed: 29637711
PLoS One. 2009;4(3):e4725
pubmed: 19266104
Curr Opin Immunol. 2015 Jun;34:130-6
pubmed: 25879814
J Clin Invest. 2009 Aug;119(8):2317-29
pubmed: 19662682
Arthritis Res Ther. 2017 Jun 14;19(1):137
pubmed: 28615031
J Dermatol. 2004 Apr;31(4):271-6
pubmed: 15187321
J Dermatol. 2017 Aug;44(8):885-891
pubmed: 28407292
Cytokine Growth Factor Rev. 2016 Dec;32:97-104
pubmed: 26872860
Immunity. 2019 Apr 16;50(4):892-906
pubmed: 30995505
Lancet Infect Dis. 2020 Sep;20(9):e216-e230
pubmed: 32653070
J Immunol. 2014 Apr 1;192(7):3111-20
pubmed: 24610014
Allergol Int. 2018 Jan;67(1):124-130
pubmed: 28734739
Arch Dermatol Res. 2019 Jul;311(5):389-397
pubmed: 30993401
J Dermatol. 2019 Apr;46(4):e116-e117
pubmed: 30216494
Ann N Y Acad Sci. 2018 Apr;1417(1):23-34
pubmed: 27783881
J Am Acad Dermatol. 2019 Jun;80(6):1556-1563
pubmed: 30171876
Clin Exp Allergy. 2005 Oct;35(10):1327-33
pubmed: 16238792
Front Immunol. 2019 Oct 22;10:2491
pubmed: 31695699
Nat Immunol. 2019 Aug;20(8):992-1003
pubmed: 31263279
Arch Dermatol. 2004 Feb;140(2):218-25
pubmed: 14967799
J Dermatol. 2018 Aug;45(8):e223
pubmed: 29512183
Mol Cell Biochem. 2015 Feb;400(1-2):207-12
pubmed: 25421412
Microbiol Immunol. 2018 Jan;62(1):1-13
pubmed: 29205464
Immunity. 2019 Apr 16;50(4):871-891
pubmed: 30995504
Semin Immunopathol. 2019 May;41(3):283-297
pubmed: 30891627
Dermatol Ther. 2020 Jul;33(4):e13457
pubmed: 32319132
Clin Chim Acta. 2020 Dec;511:40-46
pubmed: 33002471
Front Immunol. 2018 Aug 02;9:1682
pubmed: 30127781
J Biol Chem. 2016 Aug 5;291(32):16597-609
pubmed: 27307043
J Leukoc Biol. 2015 Dec;98(6):931-6
pubmed: 26310833
J Exp Med. 2004 Jan 5;199(1):125-30
pubmed: 14707118
Am Heart J. 2020 Feb;220:137-144
pubmed: 31812755
PLoS One. 2020 Apr 30;15(4):e0222969
pubmed: 32352958
Sci Rep. 2017 Sep 7;7(1):10833
pubmed: 28883472
Front Immunol. 2019 Jun 28;10:1507
pubmed: 31316526
Autoimmun Rev. 2021 Jul;20(7):102846
pubmed: 33971346
J Eur Acad Dermatol Venereol. 2016 Nov;30(11):1876-1885
pubmed: 27230733
J Dermatol Sci. 2012 Feb;65(2):134-40
pubmed: 22189341
Acta Derm Venereol. 2018 Jan 12;98(1):5-13
pubmed: 28967976
Sci Rep. 2020 Apr 6;10(1):5988
pubmed: 32249825
J Invest Dermatol. 2002 Jan;118(1):147-54
pubmed: 11851888
Dermatology. 2017;233(2-3):164-169
pubmed: 28654918
Curr Opin Immunol. 2017 Oct;48:68-73
pubmed: 28869867