Neurotransmitter Dysfunction in Irritable Bowel Syndrome: Emerging Approaches for Management.
IBS
colorectal motility
microbiota
visceral hypersensitivity
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
31 Jul 2021
31 Jul 2021
Historique:
received:
30
06
2021
revised:
13
07
2021
accepted:
28
07
2021
entrez:
7
8
2021
pubmed:
8
8
2021
medline:
8
8
2021
Statut:
epublish
Résumé
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder whose aetiology is still unknown. Most hypotheses point out the gut-brain axis as a key factor for IBS. The axis is composed of different anatomic and functional structures intercommunicated through neurotransmitters. However, the implications of key neurotransmitters such as norepinephrine, serotonin, glutamate, GABA or acetylcholine in IBS are poorly studied. The aim of this review is to evaluate the current evidence about neurotransmitter dysfunction in IBS and explore the potential therapeutic approaches. IBS patients with altered colorectal motility show augmented norepinephrine and acetylcholine levels in plasma and an increased sensitivity of central serotonin receptors. A decrease of colonic mucosal serotonin transporter and a downregulation of α2 adrenoceptors are also correlated with visceral hypersensitivity and an increase of 5-hydroxyindole acetic acid levels, enhanced expression of high affinity choline transporter and lower levels of GABA. Given these neurotransmitter dysfunctions, novel pharmacological approaches such as 5-HT
Identifiants
pubmed: 34362210
pii: jcm10153429
doi: 10.3390/jcm10153429
pmc: PMC8347293
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : ARAINF
ID : 2012/0567
Organisme : DGA
ID : A02_17 R
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