Collagen fiber orientation disorder from H&E images is prognostic for early stage breast cancer: clinical trial validation.


Journal

NPJ breast cancer
ISSN: 2374-4677
Titre abrégé: NPJ Breast Cancer
Pays: United States
ID NLM: 101674891

Informations de publication

Date de publication:
06 Aug 2021
Historique:
received: 13 12 2020
accepted: 25 06 2021
entrez: 7 8 2021
pubmed: 8 8 2021
medline: 8 8 2021
Statut: epublish

Résumé

Collagen fiber organization has been found to be implicated in breast cancer prognosis. In this study, we evaluated whether computerized features of Collagen Fiber Orientation Disorder in Tumor-associated Stroma (CFOD-TS) on Hematoxylin & Eosin (H&E) slide images were prognostic of Disease Free Survival (DFS) in early stage Estrogen Receptor Positive (ER+) Invasive Breast Cancers (IBC). A Cox regression model named M

Identifiants

pubmed: 34362928
doi: 10.1038/s41523-021-00310-z
pii: 10.1038/s41523-021-00310-z
pmc: PMC8346522
doi:

Types de publication

Journal Article

Langues

eng

Pagination

104

Subventions

Organisme : NCATS NIH HHS
ID : UL1 TR002548
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA216579
Pays : United States
Organisme : NCRR NIH HHS
ID : C06 RR012463
Pays : United States
Organisme : NCI NIH HHS
ID : U24 CA199374
Pays : United States
Organisme : NIBIB NIH HHS
ID : R43 EB028736
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA254566
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA239055
Pays : United States
Organisme : NCI NIH HHS
ID : UG1 CA233328
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA220581
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA202752
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA208236
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA248226
Pays : United States
Organisme : BLRD VA
ID : I01 BX004121
Pays : United States

Informations de copyright

© 2021. The Author(s).

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Auteurs

Haojia Li (H)

Case Western Reserve University, Department of Biomedical Engineering, Cleveland, OH, USA. hxl735@case.edu.

Kaustav Bera (K)

Case Western Reserve University, Department of Biomedical Engineering, Cleveland, OH, USA.

Paula Toro (P)

Case Western Reserve University, Department of Biomedical Engineering, Cleveland, OH, USA.

PingFu Fu (P)

Case Western Reserve University, Department of Population and Quantitative Health Sciences, School of Medicine, Cleveland, OH, USA.

Zelin Zhang (Z)

Nanjing University of Information Science and Technology, Jiangsu Key Laboratory of Big Data Analysis Technique, Nanjing, China.

Cheng Lu (C)

Case Western Reserve University, Department of Biomedical Engineering, Cleveland, OH, USA.

Michael Feldman (M)

University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Shridar Ganesan (S)

Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.

Lori J Goldstein (LJ)

Fox Chase Cancer Center, Philadelphia, PA, USA.

Nancy E Davidson (NE)

Fred Hutchinson Cancer Research Center, University of Washington, and Seattle Cancer Care Alliance, Seattle, WA, USA.

Akisha Glasgow (A)

University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

Aparna Harbhajanka (A)

University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

Hannah Gilmore (H)

University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

Anant Madabhushi (A)

Case Western Reserve University, Department of Biomedical Engineering, Cleveland, OH, USA. axm788@case.edu.
Louis Stokes Cleveland Veterans Administration Medical Center, Cleveland, OH, USA. axm788@case.edu.

Classifications MeSH