Retinoblastoma associated with orbital pseudocellulitis and high-risk retinoblastoma: a study of 32 eyes.
Cancer
Cellulitis
Eye
High-risk retinoblastoma
Pseudocellulitis
Retinoblastoma
Tumor
Journal
International ophthalmology
ISSN: 1573-2630
Titre abrégé: Int Ophthalmol
Pays: Netherlands
ID NLM: 7904294
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
11
05
2021
accepted:
24
07
2021
pubmed:
8
8
2021
medline:
3
2
2022
entrez:
7
8
2021
Statut:
ppublish
Résumé
To study the correlation between retinoblastoma (RB) associated with orbital pseudocellulitis and high-risk histopathology features. Retrospective study of 32 patients who underwent primary enucleation for RB presenting with orbital pseudocellulitis. All RB patients presented with orbital pseudocellulitis. The mean age at presentation of RB was 30 months (median, 24 months; range, 3-70 months). There were 14 (44%) males and 18 (56%) females. All patients were referred with a diagnosis of RB with orbital pseudocellulitis. Tumor was bilateral in 12 (38%) patients but orbital pseudocellulitis was unilateral in all cases. The pseudocellulitis features included proptosis (n = 9; 28%), eyelid edema (n = 22; 69%), conjunctival congestion (n = 23; 72%), and conjunctival chemosis (n = 15; 47%). Based on clinical features and orbital imaging, all patients were diagnosed to have group E intraocular RB. All patients received intravenous steroids prior to enucleation. On histopathology, tumor necrosis was present in all cases with a mean % necrosis of 60% (median, 60%; range, 10% to 90%). Most tumors (72%) were poorly differentiated. High-risk histopathology features were noted in 23 (72%) cases and adjuvant chemotherapy was advised for all these patients. The most common high-risk histopathology features included post-laminar optic nerve infiltration (34%) and scleral infiltration (22%). Over a mean follow-up period of 34 months (median, 9 months; range, < 1-188 months), there was no event of metastasis or death in any patient. RB presenting with orbital pseudocellulitis is associated with high incidence of high-risk histopathology features.
Identifiants
pubmed: 34363179
doi: 10.1007/s10792-021-01993-w
pii: 10.1007/s10792-021-01993-w
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
19-26Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Nature B.V.
Références
Abramson DH, Frank CM, Susman M, Whalen MP, Dunkel IJ, Boyd NW 3rd (1998) Presenting signs of retinoblastoma. J Pediatr 132(3 Pt 1):505–508
doi: 10.1016/S0022-3476(98)70028-9
Agarwal M, Biswas J, Shanmugam MP (2004) Retinoblastoma presenting as orbital cellulitis: report of four cases with a review of the literature. Orbit 23(2):93–98
doi: 10.1080/01676830490501514
Al Rashaed S, Elkhamary SM, Al Sheikh O, Al Mesfer S, Al-Dhibi H, Al MA (2020) Adult presentation of retinoblastoma in Saudi patient. Saudi J Ophthalmol 34(2):136–138
doi: 10.4103/1319-4534.305046
Balasubramanya R, Pushker N, Bajaj MS, Ghose S, Kashyap S, Rani A (2004) Atypical presentations of retinoblastoma. J Pediatr Ophthalmol Strabismus 41(1):18–24
doi: 10.3928/0191-3913-20040101-06
Ben Meir A, Bardenstein D, Peiffer R (1995) Retinoblastoma presenting with orbital cellulitis: a mechanical hypothesis. Invest Ophthalmol Vis Sci 36:492
Chong EM, Coffee RE, Chintagumpala M, Hurwitz RL, Hurwitz MY, Chévez-Barrios P (2006) Extensively necrotic retinoblastoma is associated with high-risk prognostic factors. Arch Pathol Lab Med 130(11):1669–1672
doi: 10.5858/2006-130-1669-ENRIAW
Foster BS, Mukai S (1996) Intraocular retinoblastoma presenting as ocular and orbital inflammation. Int Ophthalmol Clin 36(1):153–160
doi: 10.1097/00004397-199603610-00016
Kaliki S (2018) How to do an enucleation for retinoblastoma. Community Eye Health 31(101):20–22
pubmed: 29915465
pmcid: 5998390
Kaliki S, Gupta S, Ramappa G, Mohamed A, Mishra DK (2020) High-risk retinoblastoma based on age at primary enucleation: a study of 616 eyes. Eye (Lond) 34(8):1441–1448
doi: 10.1038/s41433-019-0698-2
Kaliki S, Patel A, Iram S, Palkonda VAR (2017) Clinical presentation and outcomes of stage III or stage IV retinoblastoma in 80 Asian Indian patients. J Pediatr Ophthalmol Strabismus 54(3):177–184
doi: 10.3928/01913913-20161019-01
Kaliki S, Patel A, Iram S, Ramappa G, Mohamed A, Palkonda VAR (2019) Retinoblastoma in India: clinical presentation and outcome in 1,457 patients (2,074 Eyes). Retina 39(2):379–391
doi: 10.1097/IAE.0000000000001962
Kaliki S, Shields CL, Eagle RC Jr, Iram S, Shields JA (2018) High-risk intraocular retinoblastoma: comparison between Asian Indians and Americans from two major referral centers. Retina 38(10):2023–2029
doi: 10.1097/IAE.0000000000001816
Martino F, Gelmi MC, Galluzzi P, De Francesco S, Miracco C, Hadjistilianou D (2020) Orbital pseudocellulitis: a retinoblastoma-associated masquerade syndrome. Ocul Oncol Pathol 6(6):430–437
doi: 10.1159/000509810
Mullaney PB, Karcioglu ZA, Huaman AM, Al-Mesfer S (1998) Retinoblastoma associated orbital cellulitis. Br J Ophthalmol 82(5):517–521
doi: 10.1136/bjo.82.5.517
Nadol JB Jr (1977) Pseudocellulitis of the orbit. Ann Otol Rhinol Laryngol 86(1 Pt 1):86–88
doi: 10.1177/000348947708600114
Nalcı H, Gündüz K, Erden E (2018) Necrotic intraocular retinoblastoma associated with orbital cellulitis. Surv Ophthalmol 63(1):114–118
doi: 10.1016/j.survophthal.2017.01.010
Read RW, Zamir E, Rao NA (2002) Neoplastic masquerade syndromes. Surv Ophthalmol 47(2):81–124
doi: 10.1016/S0039-6257(01)00305-8
Sachdeva R, Schoenfield L, Marcotty A, Singh AD (2011) Retinoblastoma with autoinfarction presenting as orbital cellulitis. J AAPOS 15(3):302–304
doi: 10.1016/j.jaapos.2011.02.013
Shields JA, Shields CL, Suvarnamani C, Schroeder RP, DePotter P (1991) Retinoblastoma manifesting as orbital cellulitis. Am J Ophthalmol 112(4):442–449
doi: 10.1016/S0002-9394(14)76255-5
Walinjkar J, Krishnakumar S, Gopal L, Ramesh A, Khetan V (2013) Retinoblastoma presenting with orbital cellulitis. J AAPOS 17(3):282–286
doi: 10.1016/j.jaapos.2013.02.009