Muscle strength is associated with COVID-19 hospitalization in adults 50 years of age or older.
Coronavirus disease 2019
Hospitalization
Muscle strength
Physical fitness
Risk factors
Sarcopenia
Journal
Journal of cachexia, sarcopenia and muscle
ISSN: 2190-6009
Titre abrégé: J Cachexia Sarcopenia Muscle
Pays: Germany
ID NLM: 101552883
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
revised:
22
03
2021
received:
09
02
2021
accepted:
21
05
2021
pubmed:
8
8
2021
medline:
26
11
2021
entrez:
7
8
2021
Statut:
ppublish
Résumé
Weak muscle strength has been associated with a wide range of adverse health outcomes. Yet, whether individuals with weaker muscle strength are more at risk for hospitalization due to severe COVID-19 is still unclear. The objective of this study was to investigate the independent association between muscle strength and COVID-19 hospitalization. Data from adults 50 years of age or older were analysed using logistic models adjusted for several chronic conditions, body-mass index, age, and sex. Hand-grip strength was repeatedly measured between 2004 and 2017 using a handheld dynamometer. COVID-19 hospitalization during the lockdown was self-reported in summer 2020 and was used as an indicator of COVID-19 severity. The study was based on the Survey of Health, Ageing and Retirement in Europe (SHARE) and included 3600 older adults (68.8 ± 8.8 years, 2044 female), among whom 316 were tested positive for the severe acute respiratory syndrome coronavirus 2 (8.8%), and 83 (2.3%) were hospitalized due to COVID-19. Results showed that higher grip strength was associated with a lower risk of COVID-19 hospitalization [adjusted odds ratio (OR) per increase of 1 standard deviation in grip strength = 0.64, 95% confidence interval (95% CI) = 0.45-0.87, P = 0.015]. Results also showed that age (OR for a 10 -year period = 1.70, 95% CI = 1.32-2.20, P < 0.001) and obesity (OR = 2.01, 95% CI = 1.00-3.69, P = 0.025) were associated with higher risk of COVID-19 hospitalization. Sensitivity analyses using different measurements of grip strength as well as robustness analyses based on rare-events logistic regression and a different sample of participants (i.e. COVID-19 patients) were consistent with the main results. Muscle strength is an independent risk factor for COVID-19 severity in adults 50 years of age or older.
Sections du résumé
BACKGROUND
Weak muscle strength has been associated with a wide range of adverse health outcomes. Yet, whether individuals with weaker muscle strength are more at risk for hospitalization due to severe COVID-19 is still unclear. The objective of this study was to investigate the independent association between muscle strength and COVID-19 hospitalization.
METHODS
Data from adults 50 years of age or older were analysed using logistic models adjusted for several chronic conditions, body-mass index, age, and sex. Hand-grip strength was repeatedly measured between 2004 and 2017 using a handheld dynamometer. COVID-19 hospitalization during the lockdown was self-reported in summer 2020 and was used as an indicator of COVID-19 severity.
RESULTS
The study was based on the Survey of Health, Ageing and Retirement in Europe (SHARE) and included 3600 older adults (68.8 ± 8.8 years, 2044 female), among whom 316 were tested positive for the severe acute respiratory syndrome coronavirus 2 (8.8%), and 83 (2.3%) were hospitalized due to COVID-19. Results showed that higher grip strength was associated with a lower risk of COVID-19 hospitalization [adjusted odds ratio (OR) per increase of 1 standard deviation in grip strength = 0.64, 95% confidence interval (95% CI) = 0.45-0.87, P = 0.015]. Results also showed that age (OR for a 10 -year period = 1.70, 95% CI = 1.32-2.20, P < 0.001) and obesity (OR = 2.01, 95% CI = 1.00-3.69, P = 0.025) were associated with higher risk of COVID-19 hospitalization. Sensitivity analyses using different measurements of grip strength as well as robustness analyses based on rare-events logistic regression and a different sample of participants (i.e. COVID-19 patients) were consistent with the main results.
CONCLUSIONS
Muscle strength is an independent risk factor for COVID-19 severity in adults 50 years of age or older.
Identifiants
pubmed: 34363345
doi: 10.1002/jcsm.12738
pmc: PMC8426913
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1136-1143Subventions
Organisme : German Ministry of Education and Research
Organisme : US National Institute on Aging
ID : P01_AG08291
Organisme : US National Institute on Aging
ID : IAG_BSR06-11, OGHA_04-064
Organisme : US National Institute on Aging
ID : P30_AG12815
Organisme : US National Institute on Aging
ID : P01_AG005842
Organisme : European Commission
Organisme : US National Institute on Aging
ID : R21_AG025169
Organisme : US National Institute on Aging
ID : U01_AG09740-13S2
Organisme : Swiss National Science Foundation (SNSF)
ID : PZ00P1_180040
Organisme : NIA NIH HHS
ID : HHSN271201300071C
Pays : United States
Organisme : Natural Sciences and Engineering Research Council of Canada (NSERC) : RGPIN-2021-03153
Organisme : US National Institute on Aging
ID : Y1-AG-4553-01
Organisme : Max Planck Society for the Advancement of Science
Informations de copyright
© 2021 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders.
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