Analyses of DNA Methylation Profiling in the Diagnosis of Intramedullary Astrocytomas.
2016 WHO classification
DNA methylation profiling
Glial tumor
Intramedullary astrocytomas
Methylation array
Spinal cord
Journal
Journal of neuropathology and experimental neurology
ISSN: 1554-6578
Titre abrégé: J Neuropathol Exp Neurol
Pays: England
ID NLM: 2985192R
Informations de publication
Date de publication:
11 08 2021
11 08 2021
Historique:
pubmed:
8
8
2021
medline:
30
12
2021
entrez:
7
8
2021
Statut:
ppublish
Résumé
Intramedullary astrocytomas (IMAs) consist of a heterogeneous group of rare central nervous system (CNS) tumors associated with variable outcomes. A DNA methylation-based classification approach has recently emerged as a powerful tool to further classify CNS tumors. However, no DNA methylation-related studies specifically addressing to IMAs have been performed yet. In the present study, we analyzed 16 IMA samples subjected to morphological and molecular analyses, including DNA methylation profiling. Among the 16 samples, only 3 cases were classified in a reference methylation class (MC) with the recommended calibrated score (≥0.9). The remaining cases were either considered "no-match" cases (calibrated score <0.3, n = 7) or were classified with low calibrated scores (ranging from 0.32 to 0.53, n = 6), including inconsistent classification. To obtain a more comprehensive tool for pathologists, we used different unsupervised analyses of DNA methylation profiles, including our data and those from the Heidelberg reference cohort. Even though our cohort included only 16 cases, hypotheses regarding IMA-specific classification were underlined; a potential specific MC of PA_SPINE was identified and high-grade IMAs, probably consisting of H3K27M wild-type IMAs, were mainly associated with ANA_PA MC. These hypotheses strongly suggest that a specific classification for IMAs has to be investigated.
Identifiants
pubmed: 34363673
pii: 6345438
doi: 10.1093/jnen/nlab052
pmc: PMC8357340
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
663-673Informations de copyright
© 2021 American Association of Neuropathologists, Inc.
Références
Acta Neuropathol. 2020 Feb;139(2):305-318
pubmed: 31679042
World Neurosurg. 2017 Dec;108:991.e13-991.e16
pubmed: 28866063
Acta Neuropathol Commun. 2020 Mar 30;8(1):40
pubmed: 32228694
Clin Epigenetics. 2019 Dec 5;11(1):185
pubmed: 31806041
Ann Oncol. 2016 Apr;27(4):599-608
pubmed: 27005468
Cancer Cell. 2015 May 11;27(5):728-43
pubmed: 25965575
Epigenetics Chromatin. 2013 Mar 03;6(1):4
pubmed: 23452981
Genom Data. 2016 May 26;9:22-4
pubmed: 27330998
Acta Neuropathol. 2019 Nov;138(5):877-881
pubmed: 31515627
Cancer Med. 2020 Oct;9(19):6996-7006
pubmed: 32777166
Acta Neuropathol. 2018 Aug;136(2):181-210
pubmed: 29967940
World Neurosurg. 2017 Oct;106:113-119
pubmed: 28377242
Acta Neuropathol. 2016 Jan;131(1):147-50
pubmed: 26487540
Neurosurgery. 2019 May 1;84(5):1072-1081
pubmed: 29718432
Exp Mol Med. 2017 Apr 28;49(4):e322
pubmed: 28450738
Asian Spine J. 2016 Aug;10(4):748-54
pubmed: 27559457
Nat Genet. 2016 Jan;48(1):59-66
pubmed: 26618343
Mod Pathol. 2019 Sep;32(9):1236-1243
pubmed: 31028365
Brief Bioinform. 2014 Nov;15(6):929-41
pubmed: 23990268
Acta Neuropathol. 2018 Aug;136(2):273-291
pubmed: 29564591
Acta Neuropathol Commun. 2019 Feb 20;7(1):24
pubmed: 30786920
Neuropathol Appl Neurobiol. 2008 Jun;34(3):316-29
pubmed: 17983425
J Child Neurol. 2008 Oct;23(10):1214-20
pubmed: 18952588
Nat Genet. 2006 Dec;38(12):1359-60
pubmed: 17133218
Cancer Cell. 2012 Oct 16;22(4):425-37
pubmed: 23079654
Nature. 2018 Mar 22;555(7697):469-474
pubmed: 29539639
Acta Neuropathol Commun. 2020 Aug 28;8(1):151
pubmed: 32859279
J Clin Neurosci. 2019 May;63:168-175
pubmed: 30833131
Neuropathol Appl Neurobiol. 2020 Aug;46(5):478-492
pubmed: 32072658
Acta Neuropathol. 2020 Oct;140(4):569-581
pubmed: 32776277
Case Rep Pathol. 2016;2016:3534791
pubmed: 27313931
Acta Neuropathol. 2012 Sep;124(3):449-51
pubmed: 22772980
Nat Rev Clin Oncol. 2012 May 29;9(7):400-13
pubmed: 22641364
Oncol Lett. 2018 Oct;16(4):5405-5409
pubmed: 30250611
Oncogene. 2014 Apr 17;33(16):2019-26
pubmed: 23624918
Neuro Oncol. 2019 Nov 1;21(Suppl 5):v1-v100
pubmed: 31675094
Neurooncol Adv. 2020 Aug 24;2(1):vdaa103
pubmed: 33063010
Neuropathol Appl Neurobiol. 2020 Feb;46(1):28-47
pubmed: 31955441
Neuro Oncol. 2018 Apr 9;20(5):579-581
pubmed: 29584921
Acta Neuropathol Commun. 2020 Aug 8;8(1):128
pubmed: 32771057
Front Oncol. 2019 Jun 12;9:506
pubmed: 31263678
J Spine Surg. 2019 Mar;5(1):19-30
pubmed: 31032435
J Clin Neurosci. 2016 Jul;29:15-20
pubmed: 26944214
Acta Neuropathol. 2013 Mar;125(3):359-71
pubmed: 23291781
Acta Neuropathol Commun. 2020 Jul 14;8(1):107
pubmed: 32665022
Sci Rep. 2019 Dec 10;9(1):18722
pubmed: 31822682
Cancer. 2018 Nov 1;124(21):4168-4180
pubmed: 30255939
BMC Med Genomics. 2020 Feb 24;13(Suppl 3):27
pubmed: 32093698