Vascular permeability in chronic rhinosinusitis enhances accumulation and retention of nanoscale pegylated liposomes.

Animals Capillary Permeability Chronic Disease Humans Liposomes Mice Polyethylene Glycols Quality of Life Sinusitis / drug therapy
Chronic rhinosinusitis Inflammation Liposomes Nanocarriers Vascular permeability

Journal

Nanomedicine : nanotechnology, biology, and medicine
ISSN: 1549-9642
Titre abrégé: Nanomedicine
Pays: United States
ID NLM: 101233142

Informations de publication

Date de publication:
11 2021
Historique:
received: 08 03 2021
revised: 22 07 2021
accepted: 23 07 2021
pubmed: 8 8 2021
medline: 17 3 2022
entrez: 7 8 2021
Statut: ppublish

Résumé

Chronic rhinosinusitis (CRS) is a debilitating inflammatory disorder of the sinonasal mucosa that substantially diminishes patient quality of life. Progress surrounding management of this disease has been crippled by a lack of therapeutic innovation. It has been posited that increased vascularity within the diseased sinuses of patients with CRS may allow for improved systemic drug delivery via nanoscale liposomal carriers. Such a system could enhance drug distribution, accumulation, and retention within the sinuses, ultimately leading to improved patient outcomes. PEGylated liposomes loaded with indocyanine green (ICG) were synthesized, characterized and systemically administered in a mouse model of CRS. Accumulation and retention of ICG in sinonasal tissue were evaluated. Compared to healthy controls, CRS mice showed significant sinonasal tissue accumulation and retention of PEGylated liposomal ICG for up to 21 days (P < 0.001). Conversely, free ICG was eliminated from the body after 24 h in both groups.

Identifiants

DOI: 10.1016/j.nano.2021.102453 PMID: 34363985 PMC: PMC10499165
pubmed: 34363985
pii: S1549-9634(21)00096-4
doi: 10.1016/j.nano.2021.102453
pmc: PMC10499165
mid: NIHMS1929786
pii:
doi:

Substances chimiques

Liposomes 0
Polyethylene Glycols 3WJQ0SDW1A

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

102453

Subventions

Organisme : NCI NIH HHS
ID : R01 CA227225
Pays : United States

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

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Auteurs

Nitish Khurana (N)

Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, USA; Utah Center for Nanomedicine, University of Utah, Salt Lake City, UT, USA.

Bhuvanesh Yathavan (B)

Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, USA; Utah Center for Nanomedicine, University of Utah, Salt Lake City, UT, USA.

Jolanta Jedrzkiewicz (J)

Department of Pathology, University of Utah, Salt Lake City, UT, USA.

Amarbir S Gill (AS)

Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Utah School of Medicine, Salt Lake City, UT, USA.

Abigail Pulsipher (A)

Utah Center for Nanomedicine, University of Utah, Salt Lake City, UT, USA; Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Utah School of Medicine, Salt Lake City, UT, USA.

Jeremiah A Alt (JA)

Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, USA; Utah Center for Nanomedicine, University of Utah, Salt Lake City, UT, USA; Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Utah School of Medicine, Salt Lake City, UT, USA; Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, USA. Electronic address: Jeremiah.Alt@hsc.utah.edu.

Hamidreza Ghandehari (H)

Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, USA; Utah Center for Nanomedicine, University of Utah, Salt Lake City, UT, USA; Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Utah School of Medicine, Salt Lake City, UT, USA; Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, USA. Electronic address: hamid.ghandehari@utah.edu.

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Classifications MeSH

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questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Perméabilité capillaire › Vascular permeability in chronic...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Vascular permeability in chronic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Vascular permeability in chronic...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomimétiques › Membrane artificielle › Liposomes › Vascular permeability in chronic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Vascular permeability in chronic...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Polyéthylène glycols › Vascular permeability in chronic...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › État de santé › Qualité de vie › Vascular permeability in chronic...
questionsmedicales.fr › Maladies oto-rhino-laryngologiques › Maladies du nez › Maladies des sinus › Sinusite › Vascular permeability in chronic...