Quantitative analysis of human brain microdialysate for target site pharmacokinetics of major anesthetics ketamine, midazolam and propofol.
Cerebral microdialysis
Drug tissue concentration
In vivo pharmacokinetics
Ketamine
Midazolam
Propofol
Journal
Journal of pharmaceutical and biomedical analysis
ISSN: 1873-264X
Titre abrégé: J Pharm Biomed Anal
Pays: England
ID NLM: 8309336
Informations de publication
Date de publication:
25 Oct 2021
25 Oct 2021
Historique:
received:
09
04
2021
revised:
26
07
2021
accepted:
26
07
2021
pubmed:
9
8
2021
medline:
6
10
2021
entrez:
8
8
2021
Statut:
ppublish
Résumé
Brain microdialysis samples of intensive care patients treated with the essential anesthetics ketamine, midazolam and propofol were investigated. Importantly, despite decades of clinical use, comprehensive human cerebral pharmacokinetic data of these drugs is still missing. To encounter this apparent lack of knowledge, we combined cerebral microdialysis with leading-edge analytical instrumentation to monitor the neurochemistry of living human patients. For the quantitative analysis, high performing analytical approaches were developed that can handle minute sample volumes and possible ultralow target analyte levels. The developed methods provided detection limits below 100 ng L
Identifiants
pubmed: 34365190
pii: S0731-7085(21)00400-3
doi: 10.1016/j.jpba.2021.114289
pii:
doi:
Substances chimiques
Anesthetics
0
Anesthetics, Intravenous
0
Ketamine
690G0D6V8H
Midazolam
R60L0SM5BC
Propofol
YI7VU623SF
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
114289Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare no conflict of interest.