Mind the gap from research laboratory to clinic: Challenges and opportunities for next-generation assays in human diseases.
Assay
HIV
Influenza
SARS-CoV-2
Technology
Tuberculosis
Vaccine
Journal
Vaccine
ISSN: 1873-2518
Titre abrégé: Vaccine
Pays: Netherlands
ID NLM: 8406899
Informations de publication
Date de publication:
31 08 2021
31 08 2021
Historique:
received:
14
01
2021
revised:
24
07
2021
accepted:
26
07
2021
pubmed:
10
8
2021
medline:
24
8
2021
entrez:
9
8
2021
Statut:
ppublish
Résumé
Modern vaccinology has experienced major conceptual and technological advances over the past 30 years. These include atomic-level structures driving immunogen design, new vaccine delivery methods, powerful adjuvants, and novel animal models. In addition, utilizing advanced assays to learn how the immune system senses a pathogen and orchestrates protective immunity has been critical in the design of effective vaccines and therapeutics. The National Institute of Allergy and Infectious Diseases of the National Institutes of Health convened a workshop in September 2020 focused on next generation assays for vaccine development (Table 1). The workshop focused on four critical pathogens: severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) and human immunodeficiency virus (HIV)-which have no licensed vaccines-and tuberculosis (TB) and influenza-both of which are in critical need of improved vaccines. The goal was to share progress and lessons learned, and to identify any commonalities that can be leveraged to design vaccines and therapeutics.
Identifiants
pubmed: 34366145
pii: S0264-410X(21)00964-6
doi: 10.1016/j.vaccine.2021.07.071
pmc: PMC8343370
pii:
doi:
Types de publication
Clinical Conference
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
5233-5239Subventions
Organisme : NIAID NIH HHS
ID : UM1 AI068618
Pays : United States
Informations de copyright
Copyright © 2021.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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