Adjuvant Immune Checkpoint Inhibition in Muscle-invasive Bladder Cancer: Is It Ready for Prime Time?

Antineoplastic Combined Chemotherapy Protocols / therapeutic use Chemotherapy, Adjuvant Cystectomy Female Humans Immune Checkpoint Inhibitors / adverse effects Male Muscles Neoadjuvant Therapy Neoplasm Invasiveness Urinary Bladder Neoplasms / surgery

Journal

European urology
ISSN: 1873-7560
Titre abrégé: Eur Urol
Pays: Switzerland
ID NLM: 7512719

Informations de publication

Date de publication:
12 2021
Historique:
received: 05 07 2021
accepted: 19 07 2021
pubmed: 10 8 2021
medline: 19 4 2022
entrez: 9 8 2021
Statut: ppublish

Résumé

We discuss results from the Checkmate-274 and IMvigor010 trials on adjuvant immune checkpoint inhibitor (ICI) therapy in muscle-invasive bladder cancer (MIBC) with or without neoadjuvant chemotherapy (NAC), and conclude that adjuvant ICI (nivolumab but not atezolizumab) should be considered for patients with resected high-risk MIBC, especially for those who have received NAC.

Identifiants

DOI: 10.1016/j.eururo.2021.07.019 PMID: 34366212
pubmed: 34366212
pii: S0302-2838(21)01922-9
doi: 10.1016/j.eururo.2021.07.019
pii:
doi:

Substances chimiques

Immune Checkpoint Inhibitors 0

Types de publication

Editorial

Langues

eng

Sous-ensembles de citation

IM

Pagination

679-681

Informations de copyright

Copyright © 2021 European Association of Urology. Published by Elsevier B.V. All rights reserved.

Auteurs

Adi Kartolo (A)

Division of Medical Oncology, Department of Oncology, Queen's University, Kingston, Canada.

Wassim Kassouf (W)

Division of Urology, Department of Surgery, McGill University Health Center, Montreal, Canada.

Francisco E Vera-Badillo (FE)

Division of Medical Oncology, Department of Oncology, Queen's University, Kingston, Canada. Electronic address: francisco.verabadillo@kingstonhsc.ca.

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Classifications MeSH

questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Association de médicaments › Protocoles de polychimiothérapie antinéoplasique › Adjuvant Immune Checkpoint Inhibition in...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Traitement médicamenteux adjuvant › Adjuvant Immune Checkpoint Inhibition in...
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie urogénitale › Procédures de chirurgie urologique › Cystectomie › Adjuvant Immune Checkpoint Inhibition in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Adjuvant Immune Checkpoint Inhibition in...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Antinéoplasiques immunologiques › Inhibiteurs de points de contrôle immunitaires › Adjuvant Immune Checkpoint Inhibition in...
questionsmedicales.fr › Tissus › Muscles › Adjuvant Immune Checkpoint Inhibition in...
questionsmedicales.fr › Thérapeutique › Association thérapeutique › Traitement néoadjuvant › Adjuvant Immune Checkpoint Inhibition in...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Invasion tumorale › Adjuvant Immune Checkpoint Inhibition in...
questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Tumeurs urologiques › Tumeurs de la vessie urinaire › Adjuvant Immune Checkpoint Inhibition in...