Dysregulated liver function in SARS-CoV-2 infection: Current understanding and perspectives.
COVID-19
Cytokine storm
Dysregulated liver function
SARS-CoV-2
Journal
World journal of gastroenterology
ISSN: 2219-2840
Titre abrégé: World J Gastroenterol
Pays: United States
ID NLM: 100883448
Informations de publication
Date de publication:
21 Jul 2021
21 Jul 2021
Historique:
received:
31
01
2021
revised:
15
05
2021
accepted:
22
06
2021
entrez:
9
8
2021
pubmed:
10
8
2021
medline:
11
8
2021
Statut:
ppublish
Résumé
Since it was first reported in December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has spread rapidly around the world to cause the ongoing pandemic. Although the clinical manifestations of SARS-CoV-2 infection are predominantly in the respiratory system, liver enzyme abnormalities exist in around half of the cases, which indicate liver injury, and raise clinical concern. At present, there is no consensus whether the liver injury is directly caused by viral replication in the liver tissue or indirectly by the systemic inflammatory response. This review aims to summarize the clinical manifestations and to explore the underlying mechanisms of liver dysfunction in patients with SARS-CoV-2 infection.
Identifiants
pubmed: 34366609
doi: 10.3748/wjg.v27.i27.4358
pmc: PMC8316914
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
4358-4370Informations de copyright
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict-of-interest statement: There are no conflicts of interest to declare.
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