Blood Plasma Biomarkers for Woody Breast Disease in Commercial Broilers.
biomarker
blood plasma
metabolomics
proteomics
woody breast
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2021
2021
Historique:
received:
21
05
2021
accepted:
29
06
2021
entrez:
9
8
2021
pubmed:
10
8
2021
medline:
10
8
2021
Statut:
epublish
Résumé
Woody breast (WB) myopathy results in poor muscle quality. The increasing incidence of WB over the last several years indicates a need for improved prediction or early diagnosis. We hypothesized that the use of body fluids, including blood, may be more suitable than breast muscle tissue in developing a minimally invasive diagnostic tool for WB detection. To identify potential early-age-biomarkers that may represent the potential onset of WB, blood samples were collected from 100, 4 wks old commercial male broilers. At 8 wks of age, WB conditions were scored by manual palpation. A total of 32 blood plasma samples (eight for each group of WB and non-WB control birds at two time points, 4 wks and 8 wks) were subjected to shotgun proteomics and untargeted metabolomics to identify differentially abundant plasma proteins and metabolites in WB broilers compared to non-WB control (Con) broilers. From the proteomics assay, 25 and 16 plasma proteins were differentially abundant (
Identifiants
pubmed: 34366899
doi: 10.3389/fphys.2021.712694
pmc: PMC8339902
doi:
Types de publication
Journal Article
Langues
eng
Pagination
712694Informations de copyright
Copyright © 2021 Kong, Khatri, Kang, Shouse, Kadhim, Kidd, Lassiter, Hiltz, Mallmann, Orlowski, Anthony, Bottje, Kuenzel and Owens.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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