A Systematic Review of Anogenital Distance and Gynecological Disorders: Endometriosis and Polycystic Ovary Syndrome.
Anal Canal
/ anatomy & histology
Body Weights and Measures
Endometriosis
/ epidemiology
Female
Genital Diseases, Female
/ epidemiology
Genitalia, Female
/ anatomy & histology
Humans
Infant, Newborn
Male
Peritoneal Diseases
/ epidemiology
Polycystic Ovary Syndrome
/ epidemiology
Pregnancy
Risk Factors
androgen
anogenital distance
endometriosis
polycystic ovary syndrome
prenatal exposure
reproduction
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2021
2021
Historique:
received:
18
04
2021
accepted:
29
06
2021
entrez:
9
8
2021
pubmed:
10
8
2021
medline:
16
2
2022
Statut:
epublish
Résumé
Anogenital distance (AGD) can serve as a life-long indicator of androgen action in gestational weeks 8-14. AGD has been used as an important tool to investigate the exposure to endocrine-disrupting compounds in newborns and in individuals with male reproductive disorder. Endometriosis and polycystic ovary syndrome (PCOS) are two common gynecological disorders and both are related to prenatal androgen levels. Therefore, we performed a systematic review to evaluate the relationships of AGD with these gynecological disorders. PubMed, Web of Science, and Embase were searched for published studies up to January 25, 2021. No language restriction was implemented. Ten studies were included in this review. Five focused on women with endometriosis, and six investigated women with PCOS. According to these studies, PCOS patients had longer AGD than controls, while endometriosis patients had shorter AGD than controls. In conclusion, this study provides a detailed and accurate review of the associations of AGD with endometriosis and PCOS. The current findings indicate the longer AGD was related to PCOS and shorter AGD was related to endometriosis. However, further well-designed studies are needed to corroborate the current findings.
Sections du résumé
Background and Aim
Anogenital distance (AGD) can serve as a life-long indicator of androgen action in gestational weeks 8-14. AGD has been used as an important tool to investigate the exposure to endocrine-disrupting compounds in newborns and in individuals with male reproductive disorder. Endometriosis and polycystic ovary syndrome (PCOS) are two common gynecological disorders and both are related to prenatal androgen levels. Therefore, we performed a systematic review to evaluate the relationships of AGD with these gynecological disorders.
Methods
PubMed, Web of Science, and Embase were searched for published studies up to January 25, 2021. No language restriction was implemented.
Results
Ten studies were included in this review. Five focused on women with endometriosis, and six investigated women with PCOS. According to these studies, PCOS patients had longer AGD than controls, while endometriosis patients had shorter AGD than controls. In conclusion, this study provides a detailed and accurate review of the associations of AGD with endometriosis and PCOS.
Conclusion
The current findings indicate the longer AGD was related to PCOS and shorter AGD was related to endometriosis. However, further well-designed studies are needed to corroborate the current findings.
Identifiants
pubmed: 34367069
doi: 10.3389/fendo.2021.696879
pmc: PMC8339921
doi:
Types de publication
Journal Article
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
696879Informations de copyright
Copyright © 2021 Pan, Zhu and Zhou.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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