Comprehensive Transcriptomic Analysis Identifies Novel Antiviral Factors Against Influenza A Virus Infection.
A549 Cells
Alveolar Epithelial Cells
/ physiology
Antiviral Agents
/ metabolism
Basic-Leucine Zipper Transcription Factors
/ genetics
Gene Expression Profiling
Gene Regulatory Networks
Humans
Immune Evasion
Immunity
/ genetics
Influenza A virus
/ physiology
Influenza, Human
/ genetics
Interferons
/ metabolism
Intracellular Signaling Peptides and Proteins
/ genetics
Transcriptome
Tumor Suppressor Proteins
/ genetics
BATF2
HERC5
Influenza A virus
gene express profile
immune response
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
25
11
2020
accepted:
04
06
2021
entrez:
9
8
2021
pubmed:
10
8
2021
medline:
27
10
2021
Statut:
epublish
Résumé
Influenza A virus (IAV) has a higher genetic variation, leading to the poor efficiency of traditional vaccine and antiviral strategies targeting viral proteins. Therefore, developing broad-spectrum antiviral treatments is particularly important. Host responses to IAV infection provide a promising approach to identify antiviral factors involved in virus infection as potential molecular drug targets. In this study, in order to better illustrate the molecular mechanism of host responses to IAV and develop broad-spectrum antiviral drugs, we systematically analyzed mRNA expression profiles of host genes in a variety of human cells, including transformed and primary epithelial cells infected with different subtypes of IAV by mining 35 microarray datasets from the GEO database. The transcriptomic results showed that IAV infection resulted in the difference in expression of amounts of host genes in all cell types, especially those genes participating in immune defense and antiviral response. In addition, following the criteria of
Identifiants
pubmed: 34367124
doi: 10.3389/fimmu.2021.632798
pmc: PMC8337049
doi:
Substances chimiques
Antiviral Agents
0
Basic-Leucine Zipper Transcription Factors
0
Batf2 protein, human
0
HERC5 protein, human
0
Intracellular Signaling Peptides and Proteins
0
Tumor Suppressor Proteins
0
Interferons
9008-11-1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
632798Informations de copyright
Copyright © 2021 Zhou, Dong, Liu and Tang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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