Primary Intramedullary Spinal Melanoma: A Rare Disease of the Spinal Cord.
adjuvant radiation therapy
cancer-immunotherapy
neuro oncology
non cutaneous malignant melanoma
primary spinal melanoma
rare brain tumors
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
accepted:
05
07
2021
entrez:
9
8
2021
pubmed:
10
8
2021
medline:
10
8
2021
Statut:
epublish
Résumé
Primary malignant melanoma of the intramedullary region of the spinal cord has rarely been reported in the literature. These tumors can have variable appearance on magnetic resonance imaging (MRI) due to different extents of melanin and hemorrhage. Histopathologic confirmation and a comprehensive workup to rule out extra-spinal melanoma are required to make definitive diagnosis. We present a case of a patient diagnosed with primary intramedullary spinal melanoma in his lower thoracic spinal cord who was effectively treated with surgical resection, adjuvant radiation, and adjuvant immunotherapy. Gross total resection (GTR) is most vital in the management of this spinal tumor. Although several studies have established the efficacy of immunotherapy agents in advanced malignant melanoma, the use of these agents has not been studied in primary central nervous system melanomas. This case provides insight into the diagnostic approach and treatment options for this unique malignancy.
Identifiants
pubmed: 34367798
doi: 10.7759/cureus.16194
pmc: PMC8336382
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e16194Informations de copyright
Copyright © 2021, Tuz Zahra et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Case Rep Oncol Med. 2015;2015:293802
pubmed: 26294993
World J Surg Oncol. 2016 Sep 01;14(1):235
pubmed: 27586680
World Neurosurg. 2018 Jun;114:408-420
pubmed: 29614357
Brain Pathol. 2015 Mar;25(2):209-26
pubmed: 25534128
Am J Dermatopathol. 1991 Dec;13(6):543-50
pubmed: 1725245
J Int Med Res. 2020 Oct;48(10):300060520966152
pubmed: 33103574
J Clin Neurosci. 2010 Oct;17(10):1227-32
pubmed: 20558070
J Neurol Neurosurg Psychiatry. 1976 Jun;39(6):526-30
pubmed: 950562
Spine J. 2016 Aug;16(8):e499-500
pubmed: 26806813
J Neurosurg. 1998 Oct;89(4):659-66
pubmed: 9761064
Transl Oncol. 2019 Feb;12(2):350-360
pubmed: 30502589
World Neurosurg. 2019 Oct;130:e1091-e1097
pubmed: 31323401
AJNR Am J Neuroradiol. 2001 Nov-Dec;22(10):1864-6
pubmed: 11733317
Radiographics. 2009 Sep-Oct;29(5):1503-24
pubmed: 19755608
Oncol Lett. 2015 Oct;10(4):2171-2175
pubmed: 26622814
Front Oncol. 2017 Sep 25;7:230
pubmed: 28993799
Radiology. 2005 May;235(2):580-6
pubmed: 15858097
Brain Pathol. 2015 Mar;25(2):202-8
pubmed: 25399693
Neurosurgery. 2016 Jan;78(1):142-55
pubmed: 26355366