The Use of Genotoxicity Endpoints as Biomarkers of Low Dose Radiation Exposure in Interventional Cardiology.
cardiac interventional procedures
chromosomal aberrations
low dose radiation effects
micronuclei
γ-H2AX foci
Journal
Frontiers in public health
ISSN: 2296-2565
Titre abrégé: Front Public Health
Pays: Switzerland
ID NLM: 101616579
Informations de publication
Date de publication:
2021
2021
Historique:
received:
28
04
2021
accepted:
25
06
2021
entrez:
9
8
2021
pubmed:
10
8
2021
medline:
12
8
2021
Statut:
epublish
Résumé
The effect of the reportedly low ionizing radiation doses, such as those very often delivered to patients in interventional cardiology, remains ambiguous. As interventional cardiac procedures may have a significant impact on total collective effective dose, there are radiation protection concerns for patients and physicians regarding potential late health effects. Given that very low doses (<100 mSv) are expected to be delivered during these procedures, the purpose of this study was to assess the potency and suitability of current genotoxicity biomarkers to detect and quantitate biological effects essential for risk estimation in interventional cardiology. Specifically, the biomarkers γ-H2AX foci, dicentric chromosomes, and micronuclei, which underpin radiation-induced DNA damage, were studied in blood lymphocytes of 25 adult patients before and after interventional cardiac procedures. Even though the mean values of all patients as a group for all three endpoints tested show increased yields relative to baseline following medical exposure, our results demonstrate that only the γ-H2AX biomarker enables detection of statistically significant differences at the individual level (
Identifiants
pubmed: 34368064
doi: 10.3389/fpubh.2021.701878
pmc: PMC8342993
doi:
Substances chimiques
Biomarkers
0
Histones
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
701878Informations de copyright
Copyright © 2021 Habibi, Karyofyllis, Nikolakopoulou, Papagiannis, Karaiskos, Georgakilas, Hatzi, Malakos, Kollaros, Mastorakou, Voudris and Terzoudi.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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