Zebrafish as a Model for Germ Cell Regeneration.

germ cell germline stem cell nanos2 regeneration zebrafish

Journal

Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250

Informations de publication

Date de publication:
2021
Historique:
received: 24 03 2021
accepted: 01 07 2021
entrez: 9 8 2021
pubmed: 10 8 2021
medline: 10 8 2021
Statut: epublish

Résumé

Germ cell acts as a link between transfer of genetic information and process of species evolution. Defects or malformations of germ cells can lead to infertility or tumors. Germ cell regeneration is one of the effective ways to treat the infertility. Therefore, it is of great scientific and clinical interests to dissect the cellular and molecular mechanisms underlying germ cell regeneration. Progress have already been achieved in germ cell regeneration using model organisms for decades. However, key open issues regarding the underpinning mechanisms still remain poorly understood. Zebrafish is well known for its powerful regenerative capacity to regenerate various tissues and organs. Recently, advances in genomics, genetics, microscopy, and single cell technologies have made zebrafish an attractive model to study germ cell development and regeneration. Here we review recent technologies for the study of germ cell regeneration in zebrafish, highlight the potential of germline stem cells (GSCs) in the contribution to reproductive system regeneration, and discuss the

Identifiants

pubmed: 34368134
doi: 10.3389/fcell.2021.685001
pmc: PMC8339553
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

685001

Informations de copyright

Copyright © 2021 Cao, Yang and Luo.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Zigang Cao (Z)

Jiangxi Key Laboratory of Organ Developmental Biology, College of Life Sciences, Jinggangshan University, Ji'an, China.

Qifen Yang (Q)

Institute of Developmental Biology and Regenerative Medicine, Southwest University, Chongqing, China.

Lingfei Luo (L)

Institute of Developmental Biology and Regenerative Medicine, Southwest University, Chongqing, China.

Classifications MeSH