Statins Mitigate Stress-Related Vascular Aging and Atherosclerosis in
adiponectin
atherosclerosis
chronic stress
inflammation
statins
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2021
2021
Historique:
received:
30
03
2021
accepted:
04
06
2021
entrez:
9
8
2021
pubmed:
10
8
2021
medline:
10
8
2021
Statut:
epublish
Résumé
Exposure to chronic psychosocial stress is a risk factor for atherosclerotic cardiovascular diseases. Given that the 3-hydroxy-3-methylglutaryl-coenzyme reductase inhibitor statins prevent atherogenesis, we evaluated whether pitavastatin prevents chronic stress- and high fat diet-induced vascular senescence and atherogenesis in apolipoprotein 6-week-old These findings suggested that the pitavastatin-mediated pleiotropic vasculoprotective effects are likely attributable, at least in part, to the elevation of GLP-1 and APN levels and the inhibition of diet-induced plaque inflammation, oxidative stress, and proteolysis in
Identifiants
pubmed: 34368136
doi: 10.3389/fcell.2021.687868
pmc: PMC8335539
doi:
Types de publication
Journal Article
Langues
eng
Pagination
687868Informations de copyright
Copyright © 2021 Lei, Cui, Yang, Piao, Inoue, Wu, Li, Kuzuya and Cheng.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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