Cell Cycle Commitment and the Origins of Cell Cycle Variability.
APC/CCDH1 switch
RB-E2F switch
bistable switches
cell cycle variability
heterogeneity
quiescence
restriction point
transition probability
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2021
2021
Historique:
received:
20
04
2021
accepted:
22
06
2021
entrez:
9
8
2021
pubmed:
10
8
2021
medline:
10
8
2021
Statut:
epublish
Résumé
Exit of cells from quiescence following mitogenic stimulation is highly asynchronous, and there is a great deal of heterogeneity in the response. Even in a single, clonal population, some cells re-enter the cell cycle after a sub-optimal mitogenic signal while other, seemingly identical cells, do not, though they remain capable of responding to a higher level of stimulus. This review will consider the origins of this variability and heterogeneity, both in cells re-entering the cycle from quiescence and in the context of commitment decisions in continuously cycling populations. Particular attention will be paid to the role of two interacting molecular networks, namely the RB-E2F and APC/C
Identifiants
pubmed: 34368148
doi: 10.3389/fcell.2021.698066
pmc: PMC8343065
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
698066Informations de copyright
Copyright © 2021 Brooks.
Déclaration de conflit d'intérêts
The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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