The Hematopoietic Bone Marrow Niche Ecosystem.
aging
bone marrow
hematopoiesis
leukemia
microenvironment
niche
transplantation
xenograft
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2021
2021
Historique:
received:
05
05
2021
accepted:
28
06
2021
entrez:
9
8
2021
pubmed:
10
8
2021
medline:
10
8
2021
Statut:
epublish
Résumé
The bone marrow (BM) microenvironment, also called the BM niche, is essential for the maintenance of fully functional blood cell formation (hematopoiesis) throughout life. Under physiologic conditions the niche protects hematopoietic stem cells (HSCs) from sustained or overstimulation. Acute or chronic stress deregulates hematopoiesis and some of these alterations occur indirectly via the niche. Effects on niche cells include skewing of its cellular composition, specific localization and molecular signals that differentially regulate the function of HSCs and their progeny. Importantly, while acute insults display only transient effects, repeated or chronic insults lead to sustained alterations of the niche, resulting in HSC deregulation. We here describe how changes in BM niche composition (ecosystem) and structure (remodeling) modulate activation of HSCs
Identifiants
pubmed: 34368155
doi: 10.3389/fcell.2021.705410
pmc: PMC8339972
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
705410Informations de copyright
Copyright © 2021 Fröbel, Landspersky, Percin, Schreck, Rahmig, Ori, Nowak, Essers, Waskow and Oostendorp.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Elife. 2015 Mar 30;4:e05521
pubmed: 25821987
Exp Hematol. 2014 Jun;42(6):487-94.e1
pubmed: 24530466
Biochem Biophys Res Commun. 2002 Nov 15;298(5):731-7
pubmed: 12419314
Nature. 2003 Oct 23;425(6960):841-6
pubmed: 14574413
Nature. 2014 Aug 14;512(7513):198-202
pubmed: 25079315
Int J Cell Cloning. 1991 Sep;9(5):451-60
pubmed: 1720154
Blood. 1990 Nov 15;76(10):2153-8
pubmed: 1700732
Cell Rep. 2012 Oct 25;2(4):964-75
pubmed: 23084748
Gerontology. 2002 Mar-Apr;48(2):62-71
pubmed: 11867927
Br J Haematol. 2003 Sep;122(5):837-46
pubmed: 12930398
Biol Blood Marrow Transplant. 2013 Nov;19(11):1566-73
pubmed: 23916672
Blood. 1994 Sep 15;84(6):1737-46
pubmed: 7521686
Leukemia. 2016 Sep;30(9):1938-42
pubmed: 27109510
Cell. 2007 Jun 15;129(6):1097-110
pubmed: 17574023
Leukemia. 2012 Jul;26(7):1594-601
pubmed: 22266913
Haematologica. 2017 Mar;102(3):445-453
pubmed: 27742772
N Engl J Med. 2014 Dec 25;371(26):2477-87
pubmed: 25426838
Nature. 2014 Jan 23;505(7484):555-8
pubmed: 24451543
Cancer Cells. 1991 Dec;3(12):480-7
pubmed: 1726456
Blood. 2012 Aug 30;120(9):1831-42
pubmed: 22802336
Immunity. 2002 Sep;17(3):277-88
pubmed: 12354381
Nat Med. 2018 Jun;24(6):782-791
pubmed: 29736022
Blood. 1996 Jan 1;87(1):73-82
pubmed: 8547679
Stem Cells. 2016 Sep;34(9):2381-92
pubmed: 27299503
Nature. 1994 Jun 16;369(6481):568-71
pubmed: 8202159
Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9355-8
pubmed: 8415706
Blood. 2014 Aug 28;124(9):1393-403
pubmed: 24990886
Leuk Res. 2013 Feb;37(2):214-20
pubmed: 23174192
Cell Stem Cell. 2016 May 5;18(5):668-81
pubmed: 27053300
Leukemia. 2014 Sep;28(9):1851-60
pubmed: 24518205
Blood. 2011 Jan 13;117(2):429-39
pubmed: 20833981
Cell Stem Cell. 2018 Sep 6;23(3):370-381.e5
pubmed: 30100167
Support Care Cancer. 2021 Jun 16;:
pubmed: 34131848
J Exp Med. 1994 May 1;179(5):1677-82
pubmed: 7513014
Blood. 1994 Jun 1;83(11):3138-45
pubmed: 7514900
Nat Immunol. 2017 Jul;18(7):753-761
pubmed: 28553950
Cell Stem Cell. 2014 Jun 5;14(6):824-37
pubmed: 24704494
Exp Cell Res. 2010 Oct 1;316(16):2609-17
pubmed: 20599957
Stem Cell Reports. 2015 Nov 10;5(5):702-715
pubmed: 26527384
Nat Med. 2014 Nov;20(11):1315-20
pubmed: 25326802
Nature. 2019 May;569(7755):222-228
pubmed: 30971824
Blood. 2009 Sep 10;114(11):2333-43
pubmed: 19433859
Cell Stem Cell. 2009 Aug 7;5(2):157-67
pubmed: 19664990
Blood. 2019 Oct 10;134(15):1214-1226
pubmed: 31366622
Blood. 1998 Jun 1;91(11):4084-91
pubmed: 9596653
Nat Immunol. 2007 Dec;8(12):1313-23
pubmed: 17982459
Nature. 2015 Oct 1;526(7571):126-30
pubmed: 26416744
Elife. 2020 Apr 14;9:
pubmed: 32286228
PLoS One. 2017 Aug 15;12(8):e0182801
pubmed: 28809927
J Exp Med. 2000 Nov 6;192(9):1365-72
pubmed: 11067884
Blood. 2009 Jul 2;114(1):49-59
pubmed: 19417209
Cell Stem Cell. 2018 Aug 02;23(2):193-209.e5
pubmed: 30017591
J Exp Med. 2017 Jan;214(1):165-181
pubmed: 27998927
Nat Methods. 2009 Apr;6(4):267-9
pubmed: 19270698
Nature. 2009 Apr 16;458(7240):904-8
pubmed: 19212321
Cell Stem Cell. 2016 Apr 7;18(4):508-21
pubmed: 26996598
Blood. 2014 Oct 30;124(18):2834-46
pubmed: 25139351
Nature. 2014 Aug 7;512(7512):78-81
pubmed: 25043017
Blood. 1993 Dec 15;82(12):3580-91
pubmed: 8260697
Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2378-83
pubmed: 21262827
Nature. 2013 Mar 14;495(7440):231-5
pubmed: 23434755
Blood Adv. 2019 Aug 13;3(15):2424-2435
pubmed: 31409584
J Cell Physiol. 2019 Feb 10;:
pubmed: 30740681
Stem Cell Reports. 2016 Oct 11;7(4):591-601
pubmed: 27618723
J Clin Invest. 2020 Jun 1;130(6):3038-3050
pubmed: 32364536
Stem Cells Dev. 2007 Oct;16(5):707-17
pubmed: 17999593
Cell Rep. 2013 Sep 12;4(5):1022-34
pubmed: 24012753
Cells. 2020 Jan 15;9(1):
pubmed: 31952360
Exp Hematol. 2019 Aug;76:24-37
pubmed: 31408689
Cancer Res. 2017 Jul 1;77(13):3685-3699
pubmed: 28536276
Cancer Cell. 2018 Jan 8;33(1):29-43.e7
pubmed: 29249691
Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):12982-12987
pubmed: 29087299
Cell Stem Cell. 2018 Oct 4;23(4):572-585.e7
pubmed: 30174297
Blood. 2017 Apr 6;129(14):2021-2032
pubmed: 28096092
Nature. 2003 Oct 23;425(6960):836-41
pubmed: 14574412
Haematologica. 2020 Mar;105(3):661-673
pubmed: 31289202
Nature. 2021 Mar;591(7850):438-444
pubmed: 33627868
J Exp Med. 2014 Feb 10;211(2):209-15
pubmed: 24446490
Can J Physiol Pharmacol. 2017 Jul;95(7):773-786
pubmed: 28177678
Cell Rep. 2019 Dec 3;29(10):3313-3330.e4
pubmed: 31801092
Exp Hematol. 2010 Feb;38(2):82-9
pubmed: 19945502
Stem Cell Reports. 2015 Feb 10;4(2):171-80
pubmed: 25601207
Stem Cells. 2006 Jun;24(6):1564-72
pubmed: 16527900
Nat Med. 2006 Aug;12(8):933-8
pubmed: 16862154
Nature. 2013 Oct 31;502(7473):637-43
pubmed: 24107994
Blood. 2013 Jun 27;121(26):5238-49
pubmed: 23667055
Cell Stem Cell. 2019 Oct 3;25(4):570-583.e7
pubmed: 31279774
Leukemia. 2019 Aug;33(8):2034-2046
pubmed: 30737486
Cancer Cell. 2013 Jan 14;23(1):77-92
pubmed: 23328482
Cell Stem Cell. 2017 Aug 3;21(2):225-240.e5
pubmed: 28736216
J Orthop Sci. 1999;4(6):431-8
pubmed: 10664426
Blood. 2019 Aug 29;134(9):727-740
pubmed: 31311815
Nat Med. 2010 Apr;16(4):475-82
pubmed: 20305662
Nature. 2013 Mar 14;495(7440):227-30
pubmed: 23434756
Dev Cell. 2003 Feb;4(2):241-51
pubmed: 12586067
J Exp Med. 2005 Apr 18;201(8):1307-18
pubmed: 15837815
Science. 1999 Feb 5;283(5403):845-8
pubmed: 9933168
Immunity. 1996 Nov;5(5):491-501
pubmed: 8934575
iScience. 2020 Jun 26;23(6):101222
pubmed: 32535025
Nature. 2014 Feb 13;506(7487):240-4
pubmed: 24429522
Cell. 2011 Nov 23;147(5):1146-58
pubmed: 22118468
Blood. 1996 Jun 15;87(12):4998-5005
pubmed: 8652812
Cell. 2007 Jun 15;129(6):1081-95
pubmed: 17574022
Nature. 2014 Mar 20;507(7492):323-328
pubmed: 24646994
Circ Res. 2018 Aug 3;123(4):415-427
pubmed: 29980569
Immunity. 1998 Nov;9(5):677-86
pubmed: 9846489
Blood Adv. 2019 Jul 23;3(14):2128-2143
pubmed: 31300420
Mol Cell Biol. 2003 Dec;23(24):9349-60
pubmed: 14645544
Blood. 2013 Feb 7;121(6):930-9
pubmed: 23160461
Science. 2008 Dec 19;322(5909):1861-5
pubmed: 19095944
Cell Tissue Kinet. 1977 Mar;10(2):121-6
pubmed: 856473
J Cell Physiol. 2015 Feb;230(2):296-307
pubmed: 24962433
JCI Insight. 2019 Apr 18;5:
pubmed: 30998506
Cell Stem Cell. 2019 Mar 7;24(3):477-486.e6
pubmed: 30661958
Biochem Biophys Res Commun. 1993 Aug 31;195(1):301-9
pubmed: 8395828
Blood Adv. 2018 Feb 13;2(3):299-307
pubmed: 29440002
Cell Stem Cell. 2021 Jun 3;28(6):1057-1073.e7
pubmed: 33571444
Science. 2016 Dec 2;354(6316):1156-1160
pubmed: 27738012
Blood. 2003 Apr 15;101(8):2990-5
pubmed: 12672695
Nat Cell Biol. 2017 Aug;19(8):891-903
pubmed: 28714970
Nature. 2019 Jul;571(7763):117-121
pubmed: 31142833
Science. 1999 Apr 2;284(5411):143-7
pubmed: 10102814
Nature. 2010 Apr 8;464(7290):852-7
pubmed: 20305640
Exp Hematol. 2003 Feb;31(2):109-17
pubmed: 12591275
Blood. 1996 Jun 1;87(11):4544-51
pubmed: 8639822
Nat Med. 2007 Jun;13(6):742-7
pubmed: 17486088
Cell. 2019 Jun 13;177(7):1915-1932.e16
pubmed: 31130381
Immunity. 1999 May;10(5):547-58
pubmed: 10367900
Elife. 2019 Jan 11;8:
pubmed: 30632962
Cell Stem Cell. 2017 Aug 3;21(2):241-255.e6
pubmed: 28777945
Cell Stem Cell. 2016 Nov 3;19(5):613-627
pubmed: 27666011
J Vis Exp. 2017 Aug 1;(126):
pubmed: 28809828
Nat Med. 2019 Nov;25(11):1761-1771
pubmed: 31700184
Blood. 2011 Sep 8;118(10):2712-22
pubmed: 21791434
Leuk Res. 1992;16(1):15-33
pubmed: 1732665
Sci Rep. 2021 Mar 15;11(1):5944
pubmed: 33723276
Cell Stem Cell. 2008 Jul 3;3(1):85-98
pubmed: 18593561
Eur J Cancer. 1994;30A(11):1631-5
pubmed: 7530471
Immunity. 2019 Aug 20;51(2):351-366.e6
pubmed: 31303400
Front Cell Dev Biol. 2021 Mar 12;9:622519
pubmed: 33777933
Science. 1999 Apr 30;284(5415):770-6
pubmed: 10221902
Int J Hematol. 1991 Aug;54(4):299-306
pubmed: 1723315
Acad Radiol. 2009 Jun;16(6):733-8
pubmed: 19297208
J Exp Med. 2001 Oct 1;194(7):1003-12
pubmed: 11581321
Cell Stem Cell. 2019 Sep 5;25(3):407-418.e6
pubmed: 31303548
Cell. 2004 Jul 23;118(2):149-61
pubmed: 15260986
Calcif Tissue Int. 2005 Apr;76(4):299-306
pubmed: 15812580
Cell Stem Cell. 2007 Dec 13;1(6):685-97
pubmed: 18371409
Blood. 2010 May 6;115(18):3704-7
pubmed: 20207983
Stem Cells. 2004;22(7):1128-33
pubmed: 15579633
Blood. 2004 Sep 15;104(6):1688-95
pubmed: 15178584
Nat Cell Biol. 2017 Mar;19(3):214-223
pubmed: 28218906
Nat Med. 2014 Dec;20(12):1472-8
pubmed: 25326804
J Exp Med. 2005 Jun 6;201(11):1781-91
pubmed: 15928197
Bone Marrow Transplant. 2020 Jun;55(6):1029-1040
pubmed: 31804621
Cell Stem Cell. 2008 Apr 10;2(4):313-9
pubmed: 18397751
Blood. 1996 Jul 1;88(1):82-8
pubmed: 8704205
Proc Natl Acad Sci U S A. 1994 May 10;91(10):4480-4
pubmed: 7514305
J Cell Physiol. 2009 Apr;219(1):143-51
pubmed: 19107841
J Clin Invest. 2017 Nov 1;127(11):4163-4178
pubmed: 29035282
Front Immunol. 2016 Sep 16;7:362
pubmed: 27695456
Nature. 2008 Mar 27;452(7186):442-7
pubmed: 18256599
Ann Rheum Dis. 2010 Jan;69(1):284-90
pubmed: 19196726
Nature. 2009 Jul 9;460(7252):259-63
pubmed: 19516257
Cell Stem Cell. 2018 Jan 4;22(1):64-77.e6
pubmed: 29276143
Science. 2018 Apr 6;360(6384):106-110
pubmed: 29622652
Nat Med. 2014 Nov;20(11):1321-6
pubmed: 25326798
Cell Stem Cell. 2007 Dec 13;1(6):671-84
pubmed: 18371408
Nucleic Acids Res. 2021 Jan 8;49(D1):D480-D489
pubmed: 33237286
Cell Rep. 2017 Jun 13;19(11):2345-2356
pubmed: 28614719
Nature. 2015 Apr 23;520(7548):549-52
pubmed: 25707806
Blood. 2005 Aug 15;106(4):1232-9
pubmed: 15845900
Nature. 2011 Jun 08;474(7350):216-9
pubmed: 21654805
Blood. 2004 Apr 15;103(8):2942-9
pubmed: 15070669
Blood. 1974 Sep;44(3):385-92
pubmed: 4604666
J Exp Med. 2016 Sep 19;213(10):1961-71
pubmed: 27573814
Mediators Inflamm. 2015;2015:347270
pubmed: 26696752
Nat Rev Cancer. 2010 Feb;10(2):116-29
pubmed: 20094046
Haematologica. 2020 Jan;105(1):136-147
pubmed: 31018977
Cell Stem Cell. 2013 Aug 1;13(2):175-89
pubmed: 23910084
J Exp Med. 2014 Feb 10;211(2):217-31
pubmed: 24446491
Blood. 2012 Aug 30;120(9):1843-55
pubmed: 22645180
Aging Cell. 2019 Jun;18(3):e12933
pubmed: 30828977
Nat Cell Biol. 2019 Nov;21(11):1309-1320
pubmed: 31685996
N Engl J Med. 2014 Dec 25;371(26):2488-98
pubmed: 25426837
Stem Cell Reports. 2018 May 8;10(5):1625-1641
pubmed: 29742393
Elife. 2016 Dec 13;5:
pubmed: 27976999
J Clin Invest. 2010 Oct;120(10):3455-65
pubmed: 20877012
PLoS One. 2018 Mar 19;13(3):e0194688
pubmed: 29554149
Proc Natl Acad Sci U S A. 2019 Dec 3;116(49):24610-24619
pubmed: 31727843
Exp Hematol. 2021 Jan;93:52-60.e1
pubmed: 33276046
J Exp Med. 2001 Mar 19;193(6):741-54
pubmed: 11257140
J Exp Med. 2004 Jan 5;199(1):5-14
pubmed: 14707111
Nature. 2012 Jan 25;481(7382):457-62
pubmed: 22281595
Cell Stem Cell. 2021 Apr 1;28(4):637-652.e8
pubmed: 33301706
Blood. 1998 Feb 1;91(3):879-89
pubmed: 9446648
Cell Stem Cell. 2014 Dec 4;15(6):791-804
pubmed: 25479752
Transplantation. 1974 Apr;17(4):331-40
pubmed: 4150881
Cell Stem Cell. 2014 Aug 7;15(2):227-38
pubmed: 25017720
Nat Cell Biol. 2020 Dec;22(12):1399-1410
pubmed: 33230302
Cell. 2006 Jan 27;124(2):407-21
pubmed: 16439213
Aging Cell. 2017 Aug;16(4):693-703
pubmed: 28401730
Nature. 2009 Jan 1;457(7225):92-6
pubmed: 19052546
Nat Cell Biol. 2020 Jan;22(1):38-48
pubmed: 31871321
Immunity. 2006 Dec;25(6):977-88
pubmed: 17174120
Nature. 2021 Feb;590(7846):457-462
pubmed: 33568812
Stem Cell Reports. 2016 Sep 13;7(3):425-438
pubmed: 27499200
Cytokine. 2005 Nov 3;32(3-4):155-62
pubmed: 16256361
Blood. 2021 Jun 17;137(24):3339-3350
pubmed: 33881475
Blood Adv. 2018 Dec 11;2(23):3447-3461
pubmed: 30518537
Nat Med. 2013 Nov;19(11):1513-7
pubmed: 24162813
Curr Stem Cell Rep. 2017;3(3):202-209
pubmed: 28845387
Cell Rep. 2019 Jul 9;28(2):302-311.e5
pubmed: 31291568