Usefulness of metagenomic next-generation sequencing in adenovirus 7-induced acute respiratory distress syndrome: A case report.
Acute respiratory distress syndrome
Adenovirus
Case report
Metagenomic next-generation sequencing
Journal
World journal of clinical cases
ISSN: 2307-8960
Titre abrégé: World J Clin Cases
Pays: United States
ID NLM: 101618806
Informations de publication
Date de publication:
26 Jul 2021
26 Jul 2021
Historique:
received:
18
03
2021
revised:
26
04
2021
accepted:
07
05
2021
entrez:
9
8
2021
pubmed:
10
8
2021
medline:
10
8
2021
Statut:
ppublish
Résumé
Direct metagenomic next-generation sequencing (mNGS) of clinical samples is an effective method for the molecular diagnosis of infection. However, its role in the diagnosis of patients with acute respiratory distress syndrome (ARDS) of an unknown infectious etiology remains unclear. A 33-year-old man was admitted to our center for a cough and febrile sensation. Shortly after admission, the patient was diagnosed with ARDS and treated in the intensive care unit. Subsequently, chest computed tomography features suggested an infection. mNGS was performed and the results were indicative of an infection caused by adenovirus type 7. The patient recovered after receiving appropriate treatment. mNGS is a promising tool for the diagnosis of ARDS caused by infectious agents. However, further studies are required to develop strategies for incorporating mNGS into the current diagnostic process for the disease.
Sections du résumé
BACKGROUND
BACKGROUND
Direct metagenomic next-generation sequencing (mNGS) of clinical samples is an effective method for the molecular diagnosis of infection. However, its role in the diagnosis of patients with acute respiratory distress syndrome (ARDS) of an unknown infectious etiology remains unclear.
CASE SUMMARY
METHODS
A 33-year-old man was admitted to our center for a cough and febrile sensation. Shortly after admission, the patient was diagnosed with ARDS and treated in the intensive care unit. Subsequently, chest computed tomography features suggested an infection. mNGS was performed and the results were indicative of an infection caused by adenovirus type 7. The patient recovered after receiving appropriate treatment.
CONCLUSION
CONCLUSIONS
mNGS is a promising tool for the diagnosis of ARDS caused by infectious agents. However, further studies are required to develop strategies for incorporating mNGS into the current diagnostic process for the disease.
Identifiants
pubmed: 34368328
doi: 10.12998/wjcc.v9.i21.6067
pmc: PMC8316940
doi:
Types de publication
Case Reports
Langues
eng
Pagination
6067-6072Informations de copyright
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict-of-interest statement: The authors have no competing interests to declare.
Références
Semin Respir Crit Care Med. 2011 Aug;32(4):494-511
pubmed: 21858752
Am J Respir Crit Care Med. 1995 Jun;151(6):1878-88
pubmed: 7767535
Presse Med. 2011 Dec;40(12 Pt 2):e561-8
pubmed: 22094172
Am J Respir Crit Care Med. 2002 Feb 15;165(4):443-8
pubmed: 11850334
Can J Infect Dis Med Microbiol. 2020 Aug 12;2020:6839103
pubmed: 32879643
Ann Intensive Care. 2017 Dec;7(1):51
pubmed: 28500585
Front Microbiol. 2020 Aug 12;11:1879
pubmed: 32903437
Chin Med J (Engl). 2018 May 20;131(10):1220-1224
pubmed: 29595185
Crit Care Med. 2002 Nov;30(11):2450-6
pubmed: 12441753
Am J Respir Crit Care Med. 1998 Feb;157(2):645-9
pubmed: 9476884
Semin Respir Crit Care Med. 2019 Feb;40(1):31-39
pubmed: 31060086
N Engl J Med. 2000 May 4;342(18):1334-49
pubmed: 10793167
J Crit Care. 2019 Jun;51:99-104
pubmed: 30798099
J Med Virol. 2001 Dec;65(4):710-8
pubmed: 11745936
Tuberc Respir Dis (Seoul). 2016 Oct;79(4):214-233
pubmed: 27790273
Clin Microbiol Rev. 2014 Jul;27(3):441-62
pubmed: 24982316
Am J Respir Crit Care Med. 1999 Jun;159(6):1849-61
pubmed: 10351930
Infection. 2020 Aug;48(4):535-542
pubmed: 32314307
Stem Cell Res Ther. 2020 Sep 15;11(1):399
pubmed: 32933584
Anasthesiol Intensivmed Notfallmed Schmerzther. 2018 Feb;53(2):102-111
pubmed: 29426049
Eur Respir Rev. 2017 Apr 26;26(144):
pubmed: 28446599
N Engl J Med. 1972 Jun 15;286(24):1289-92
pubmed: 4337012
Sci Rep. 2019 Sep 9;9(1):12909
pubmed: 31501513