Myopathic Cardiac Genotypes Increase Risk for Myocarditis.
ACM, arrhythmogenic cardiomyopathy
AM, acute myocarditis
AM1, acute myocarditis registry 1
CMP, cardiomyopathy
DV, deleterious variant
EF, ejection fraction
ES, exome sequencing
NMD, neuromuscular disorder
OR, odds ratio
TGP, targeted gene panel
acute myocarditis
cardiomyopathy
genetics
Journal
JACC. Basic to translational science
ISSN: 2452-302X
Titre abrégé: JACC Basic Transl Sci
Pays: United States
ID NLM: 101677259
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
14
01
2021
revised:
08
06
2021
accepted:
08
06
2021
entrez:
9
8
2021
pubmed:
10
8
2021
medline:
10
8
2021
Statut:
epublish
Résumé
Impairments in certain cardiac genes confer risk for myocarditis in children. To determine the extent of this association, we performed genomic sequencing in predominantly adult patients with acute myocarditis and matched control subjects. Putatively deleterious variants in a broad set of cardiac genes were found in 19 of 117 acute myocarditis cases vs 34 of 468 control subjects
Identifiants
pubmed: 34368507
doi: 10.1016/j.jacbts.2021.06.001
pii: S2452-302X(21)00204-7
pmc: PMC8326270
doi:
Types de publication
Journal Article
Langues
eng
Pagination
584-592Subventions
Organisme : NHLBI NIH HHS
ID : K23 HL140083
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL151438
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL135742
Pays : United States
Organisme : NIH HHS
ID : S10 OD026880
Pays : United States
Informations de copyright
© 2021 The Authors.
Déclaration de conflit d'intérêts
This study is supported in part by the National Heart Lung and Blood Institute of the National Institutes of Health (HL140083 [to Dr Kontorovich]) and (HL135742 [to Dr Gelb]), a grant from the Children’s Cardiomyopathy Foundation (to Dr Kontorovich), and the German Research Foundation (KL593 2-3 [to Dr Klingel]). Research reported in this paper was supported by the Office of Research Infrastructure of the National Institutes of Health (S10OD026880). Funders had no role in the design and conduct of the study, in the collection, analysis, and interpretation of the data, or in the preparation, review, or approval of the manuscript. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
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