Mechanical Properties of Bioengineered Corneal Stroma.


Journal

Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613

Informations de publication

Date de publication:
10 2021
Historique:
revised: 15 07 2021
received: 19 05 2021
pubmed: 10 8 2021
medline: 6 11 2021
entrez: 9 8 2021
Statut: ppublish

Résumé

For the majority of patients with severe corneal injury or disease, corneal transplantation is the only suitable treatment option. Unfortunately, the demand for donor corneas greatly exceeds the availability. To overcome shortage issues, a myriad of bioengineered constructs have been developed as mimetics of the corneal stroma over the last few decades. Despite the sheer number of bioengineered stromas developed , these implants fail clinical trials exhibiting poor tissue integration and adverse effects in vivo. Such shortcomings can partially be ascribed to poor biomechanical performance. In this review, existing approaches for bioengineering corneal stromal constructs and their mechanical properties are described. The information collected in this review can be used to critically analyze the biomechanical properties of future stromal constructs, which are often overlooked, but can determine the failure or success of corresponding implants.

Identifiants

pubmed: 34369098
doi: 10.1002/adhm.202100972
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2100972

Informations de copyright

© 2021 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH.

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Auteurs

Nello Formisano (N)

Department of Instructive Biomaterials Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, 6229 ER, The Netherlands.

Cas van der Putten (C)

Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, 5612 AP, The Netherlands.

Rhiannon Grant (R)

Department of Instructive Biomaterials Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, 6229 ER, The Netherlands.

Gozde Sahin (G)

Department of Instructive Biomaterials Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, 6229 ER, The Netherlands.

Roman K Truckenmüller (RK)

Department of Instructive Biomaterials Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, 6229 ER, The Netherlands.

Carlijn V C Bouten (CVC)

Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, 5612 AP, The Netherlands.

Nicholas A Kurniawan (NA)

Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, 5612 AP, The Netherlands.

Stefan Giselbrecht (S)

Department of Instructive Biomaterials Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, 6229 ER, The Netherlands.

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