Congenital spine deformities: timing of insult during development of the spine in utero.
Spine development
Spine embryology
Journal
Spine deformity
ISSN: 2212-1358
Titre abrégé: Spine Deform
Pays: England
ID NLM: 101603979
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
25
06
2020
accepted:
28
07
2021
pubmed:
10
8
2021
medline:
17
3
2022
entrez:
9
8
2021
Statut:
ppublish
Résumé
The development of the spine and spinal cord occurs at the earliest weeks of gestation. Their development not only affects each other but also are most likely associated with anomalies in other systems. It is essential to recognize the stages of spine development to understand the cause of congenital spinal deformities and their influences on the postnatal growing spine. A vast majority of congenital spinal problems are not evident clinically. For instance, the presence of neural axis abnormalities, such as spinal dysraphism or syringomyelia, may be so subtle that patients never seek medical care. Certain vertebral formation disorders such as hemivertebrae may remain asymptomatic throughout life if they are balanced while those with congenital bars may develop severe deformity. Major defects in the spine are often associated with abnormalities of the other organs such as cardiovascular and genital urinary system that warrants close attention by multidisciplinary specialists. A thorough understanding of the basics of embryology, which serves as a window into the development of the spine, is necessary to enable the practitioner to appreciate why, when, and where the numerous spine deformities develop in utero. Besides, certain developmental defects manifest in adulthood including spondylolysis, degenerative disc disease, congenital spinal stenosis, and even tumors like cordoma. Thus, understanding embryology can assist to establish the proper diagnosis and ensure optimal treatment.
Identifiants
pubmed: 34370207
doi: 10.1007/s43390-021-00395-3
pii: 10.1007/s43390-021-00395-3
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
31-44Informations de copyright
© 2021. This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.
Références
Fleming A, Keynes RJ, Tannahill D (2001) The role of the notochord in vertebral column formation. J Anat 199(Pt 1–2):177–180
doi: 10.1046/j.1469-7580.2001.19910177.x
Oskouian RJ, Sansur CA et al (2007) Congenital abnormalities of the thoracic and lumbar spine. Neurosurg Clin N Am 18:479–498
doi: 10.1016/j.nec.2007.04.004
Moore K, Persaud TVN (2019) The developing human: clinially oriented embryology, 6th edn. W.B. Saunders Company, Philadelphia
Kaplan KM, Spivak JM et al (2005) Embryology of the spine and associated congenital abnormalities. Spine J 5:564–576
doi: 10.1016/j.spinee.2004.10.044
Schwartz ES, Rossi A (2015) congenital spine anomalies: the closed spinal dysraphisms. Pediatr Radiol 45(Suppl 3):S413–S419
doi: 10.1007/s00247-015-3425-6
Grimme JD, Castillo M (2007) Congenital anomalies of the spine. Neuroimaging Clin N Am 17(2007):1–16
doi: 10.1016/j.nic.2006.11.002
Wilson L, Maden M (2005) The mechanisms of dorsoventral patterning in the vertebrate neural tube. Dev Biol 282:1–13
doi: 10.1016/j.ydbio.2005.02.027
Gray H (2008) The anatomical basis of clinical practice. Elsevier, Amsterdam
Khorooshi MH, Hansen BF, Keeling J et al (2001) Prenatal localization of the dorsal root ganglion in different segments of the normal human vertebral column. Spine 26:1–5
doi: 10.1097/00007632-200101010-00002
Saker E, Henry BM et al (2016) The human central canal of the spinal cord: a comprehensive review of its anatomy, embryology, molecular development, variants, and pathology. Cureus 8(12):e927
pubmed: 28097078
pmcid: 5234862
George TM, Adamson DC (2015) Normal and abnormal development of the nervous system. In: Albright AL, Pollack IF, Adelson PD (eds) Principles and practice of pediatric neurosurgery. Thieme Medical Publishers, New York, pp 10–23
Chaturvedi A, Klionsky NB, Dias MS (2007) Normal and abnormal development of the spine. Neurosurg Clin N Am 18(3):415–429
doi: 10.1016/j.nec.2007.05.003
Du Plessis AJ, Volpe JJ (2018) Neural tube development. Textbook of Volpe’s Neurology of the Newborn e8:3–33
Rai AS, Taylor TK, Smith GH et al (2002) Congenital abnormalities of the urogenital tract in association with congenital vertebral malformations. J Bone Jt Surg Br 84:891–895
doi: 10.1302/0301-620X.84B6.0840891
Dias MS (2007) Normal and abnormal development of the spine. Neurosurg Clin N Am 18:415–429
doi: 10.1016/j.nec.2007.05.003
Krengel S, Gotz W, Herken R (1996) Expression pattern of type II collagen mRNA during early vertebral development in the human embryo. Anat Embryol (Berl) 193:43–51
doi: 10.1007/BF00186832
Passias PG, Poorman GW, Jalai CM et al (2017) Incidence of congenital spinal abnormalities among pediatric patients and their association with scoliosis and systemic anomalies. J Pediatr Orthop 39(8):e608–e613
doi: 10.1097/BPO.0000000000001066
Ursu TR, Porter RW, Navaratnam V (1996) Development of the lumbar and sacral vertebral canal in utero. Spine 21:2705–2708
doi: 10.1097/00007632-199612010-00001
David KM, McLachlan JC, Aiton JF et al (1998) Cartilaginous development of the human craniovertebral junction as visualised by a new three-dimensional computer reconstruction technique. J Anat 192(Pt 2):269–327
doi: 10.1046/j.1469-7580.1998.19220269.x
Bono CM, Bhallo A et al (2019) Development of the spine, Rothman-Simeone and Herkowitz’s The Spine, 7th edn. Elsevier, Amsterdam
Copley LA, Dormans JP (1998) cervical spine disorders in infants and children. J Am Acad Orthop Surg 6(4):204–214
doi: 10.5435/00124635-199807000-00002
Kim HJ (2013) Cervical spine anomalies in children and adolescents. Curr Opin Pediatr 25(1):72–77
doi: 10.1097/MOP.0b013e32835bd4cf
Hautier L, Weisbecker V, Sánchez-Villagra MR, Goswami A, Asher RJ (2010) Skeletal development in sloths and the evolution of mammalian vertebral patterning. Proc Natl Acad Sci USA 107:18903
doi: 10.1073/pnas.1010335107
Barkovich JARJ (2012) Pediatric neuroimaging, 5th edn. Lippincott Williams and Wilkins, Philadelphia
Arain A, Hornicek FJ, Schwab JH, Chebib I, Damron TA (2017) Chordoma arising from benign multifocal notochordal tumors. Skeletal Radiol 46(12):1745–1752
doi: 10.1007/s00256-017-2727-1