Effects of Opioids and Psychoactive Drugs on Blood Lipid and Glucose Indices; A Systematic Review of Population-Based Evidences.
Opioids
blood glucose.
endocrine
metabolic status
opium
psychoactive drugs
Journal
Endocrine, metabolic & immune disorders drug targets
ISSN: 2212-3873
Titre abrégé: Endocr Metab Immune Disord Drug Targets
Pays: United Arab Emirates
ID NLM: 101269157
Informations de publication
Date de publication:
2021
2021
Historique:
received:
04
03
2021
revised:
03
06
2021
accepted:
10
06
2021
pubmed:
10
8
2021
medline:
5
4
2022
entrez:
9
8
2021
Statut:
ppublish
Résumé
Based on a common belief among people, narcotic substances and psychoactive drugs may help to reduce blood glucose and lipid profile leading to reduced risk of cardiovascular diseases. This hypothesis has been verified in several studies; however, there is no conclusive agreement on the reducing effects of opium and other opioid derivatives on blood glucose and lipids. In the present review, we collected all related literature to evaluate the effects of opioids and psychoactive drugs abuse in altering blood glucose and lipid profile, and discuss their longterm effects. A systematic literature search was performed in January 2021 using "lipid profile", "glucose", and "opium" including all their equivalents, main derivatives and similar terms. The data were then extracted and reported qualitatively. Overall, 46 articles with 37407 participants were included after several step-by-step procedures of article selection. Findings of this study suggested that opioids may reduce blood glucose and low-density lipoproteins, while increasing triglyceride. However, these effects are temporary, and long-term substance abuse exacerbates glucose and lipid-associated diseases such as diabetes and atherosclerosis. Although there are many confounding factors that may affect the results of the included literature; however, based on the findings of these studies, the long-term beneficial effects of opioids on lipid profile and blood glucose cannot be accepted.
Sections du résumé
BACKGROUND
BACKGROUND
Based on a common belief among people, narcotic substances and psychoactive drugs may help to reduce blood glucose and lipid profile leading to reduced risk of cardiovascular diseases. This hypothesis has been verified in several studies; however, there is no conclusive agreement on the reducing effects of opium and other opioid derivatives on blood glucose and lipids. In the present review, we collected all related literature to evaluate the effects of opioids and psychoactive drugs abuse in altering blood glucose and lipid profile, and discuss their longterm effects.
METHODS
METHODS
A systematic literature search was performed in January 2021 using "lipid profile", "glucose", and "opium" including all their equivalents, main derivatives and similar terms. The data were then extracted and reported qualitatively.
RESULTS
RESULTS
Overall, 46 articles with 37407 participants were included after several step-by-step procedures of article selection. Findings of this study suggested that opioids may reduce blood glucose and low-density lipoproteins, while increasing triglyceride. However, these effects are temporary, and long-term substance abuse exacerbates glucose and lipid-associated diseases such as diabetes and atherosclerosis.
CONCLUSION
CONCLUSIONS
Although there are many confounding factors that may affect the results of the included literature; however, based on the findings of these studies, the long-term beneficial effects of opioids on lipid profile and blood glucose cannot be accepted.
Identifiants
pubmed: 34370658
pii: EMIDDT-EPUB-117210
doi: 10.2174/1871530321666210809155928
doi:
Substances chimiques
Analgesics, Opioid
0
Blood Glucose
0
Lipids
0
Psychotropic Drugs
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2181-2190Informations de copyright
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