Formulation and Optimization of Butenafine-Loaded Topical Nano Lipid Carrier-Based Gel: Characterization, Irritation Study, and Anti-Fungal Activity.
NLCs
anti-fungal
butenafine
irritation study
optimization
topical gel
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
16 Jul 2021
16 Jul 2021
Historique:
received:
26
06
2021
revised:
10
07
2021
accepted:
13
07
2021
entrez:
10
8
2021
pubmed:
11
8
2021
medline:
11
8
2021
Statut:
epublish
Résumé
The present study aims to prepare and optimize butenafine hydrochloride NLCs formulation using solid and liquid lipid. The optimized selected BF-NLCopt was further converted into Carbopol-based gel for topical application for the treatment of fungal infection. Box Behnken design was employed to optimize the nanostructure lipids carriers (NLCs) using the lipid content (A), Tween 80 (B), and homogenization cycle (C) as formulation factors at three levels. Their effects were observed on the particle size (Y
Identifiants
pubmed: 34371777
pii: pharmaceutics13071087
doi: 10.3390/pharmaceutics13071087
pmc: PMC8309199
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Deanship of Scientific Research, King Saud University
ID : RG-1441-443
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