Cyclodextrin Multicomponent Complexes: Pharmaceutical Applications.
auxiliary agents
complexation efficiency amino acids
organic acids
organic bases
water-soluble polymers
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
20 Jul 2021
20 Jul 2021
Historique:
received:
28
05
2021
revised:
13
07
2021
accepted:
15
07
2021
entrez:
10
8
2021
pubmed:
11
8
2021
medline:
11
8
2021
Statut:
epublish
Résumé
Cyclodextrins (CDs) are naturally available water-soluble cyclic oligosaccharides widely used as carriers in the pharmaceutical industry for their ability to modulate several properties of drugs through the formation of drug-CD complexes. The addition of an auxiliary substance when forming multicomponent complexes is an adequate strategy to enhance complexation efficiency and to facilitate the therapeutic applicability of different drugs. This review discusses multicomponent complexation using amino acids; organic acids and bases; and water-soluble polymers as auxiliary excipients. Special attention is given to improved properties by including information on the solubility, dissolution, permeation, stability and bioavailability of several relevant drugs. In addition, the use of multicomponent CD complexes to enhance therapeutic drug effects is summarized.
Identifiants
pubmed: 34371790
pii: pharmaceutics13071099
doi: 10.3390/pharmaceutics13071099
pmc: PMC8309128
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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