Pharmacodynamics of Oral Cholecalciferol in Healthy Individuals with Vitamin D Deficiency: A Randomized Open-Label Study.
bone turnover markers
cholecalciferol
osteoporosis
pharmacodynamics
supplementation
vitamin D
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
02 Jul 2021
02 Jul 2021
Historique:
received:
01
06
2021
revised:
28
06
2021
accepted:
30
06
2021
entrez:
10
8
2021
pubmed:
11
8
2021
medline:
10
9
2021
Statut:
epublish
Résumé
Comparative pharmacodynamic (PD) analyses on different dosing schedules for cholecalciferol supplementation are limited. This was an open-label, randomized, parallel-group study involving 75 healthy individuals deficient in vitamin D (baseline 25OHD < 20 ng/mL) receiving oral cholecalciferol with three different dosing regimens: Group A: 10,000 IU/day for 8 weeks followed by 1000 IU/day for 4 weeks; Group B: 50,000 IU/week for 12 weeks and Group C: 100,000 IU every other week for 12 weeks. Regulators of calcium and phosphate homeostasis, bone turnover markers and Wnt inhibitors were measured at baseline, Day 28, 53, 84, and 112. The 1,25OH2D increased at each time point. The increase was greater (
Identifiants
pubmed: 34371803
pii: nu13072293
doi: 10.3390/nu13072293
pmc: PMC8308331
pii:
doi:
Substances chimiques
Biomarkers
0
FGF23 protein, human
0
Phosphates
0
Vitamins
0
Cholecalciferol
1C6V77QF41
Fibroblast Growth Factor-23
7Q7P4S7RRE
Calcium
SY7Q814VUP
Types de publication
Clinical Trial, Phase I
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Abiogen Pharma
ID : The study was financially supported by an unrestricted grant from Abiogen Pharma, Pisa 339 Italy.
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