Frequency and Characteristics of Overestimated Renal Function in Japanese Patients with Chronic Liver Disease and Its Relation to Sarcopenia.
Adult
Aged
Aged, 80 and over
Biomarkers
/ blood
Body Composition
Chronic Disease
Creatinine
/ blood
Cystatin C
/ blood
Female
Glomerular Filtration Rate
Humans
Japan
/ epidemiology
Kidney
/ physiopathology
Kidney Diseases
/ diagnosis
Liver Diseases
/ diagnosis
Male
Middle Aged
Predictive Value of Tests
Psoas Muscles
/ diagnostic imaging
Reproducibility of Results
Retrospective Studies
Sarcopenia
/ diagnostic imaging
Tomography, X-Ray Computed
Young Adult
creatinine
liver disease
renal function
sarcopenia
skeletal muscle
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
14 Jul 2021
14 Jul 2021
Historique:
received:
21
05
2021
revised:
26
06
2021
accepted:
08
07
2021
entrez:
10
8
2021
pubmed:
11
8
2021
medline:
17
8
2021
Statut:
epublish
Résumé
Renal dysfunction and sarcopenia are important prognostic factors in patients with chronic liver disease (CLD). Muscle atrophy can cause the overestimation of renal function based on serum creatinine. However, the frequency of overestimated renal function in Japanese patients with CLD and its relationship with sarcopenia are unclear. In present study, we evaluated the frequency of overestimated renal function, defined as a >20% higher eGFR using creatinine than using cystatin C, in 307 patients with CLD as well as its relationship with indicators of sarcopenia. In total, 24.8% of patients had overestimated renal function. In a multivariate regression analysis, liver cirrhosis (
Identifiants
pubmed: 34371925
pii: nu13072415
doi: 10.3390/nu13072415
pmc: PMC8308887
pii:
doi:
Substances chimiques
Biomarkers
0
CST3 protein, human
0
Cystatin C
0
Creatinine
AYI8EX34EU
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Japan Agency for Medical Research and Development
ID : JP20fk0210072, JP20fk0210064, JP20fk0210056, JP20fk0310101, JP20fk0210047, JP20fk0210048, JP20fk0210058, JP20fk0210066, JP20fk0210067
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