The Insight into Insulin-Like Growth Factors and Insulin-Like Growth-Factor-Binding Proteins and Metabolic Profile in Pediatric Obesity.
Adipokines
/ blood
Adolescent
Biomarkers
/ blood
Case-Control Studies
Child
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Female
Gene Expression Profiling
Gene Expression Regulation
Humans
Insulin-Like Growth Factor Binding Proteins
/ blood
Insulin-Like Growth Factor I
/ analysis
Insulin-Like Growth Factor II
/ analysis
Male
Oligonucleotide Array Sequence Analysis
Pediatric Obesity
/ blood
IGF
IGFBP
children
microarray
obesity
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
15 Jul 2021
15 Jul 2021
Historique:
received:
16
06
2021
revised:
13
07
2021
accepted:
13
07
2021
entrez:
10
8
2021
pubmed:
11
8
2021
medline:
17
8
2021
Statut:
epublish
Résumé
Insulin-like growth factors (IGFs) and insulin-like growth-factor-binding proteins (IGFBPs) regulate cell proliferation and differentiation and may be of importance in obesity development. The aim of the study was to analyze the expression of chosen IGF-axis genes and the concentration of their protein products in 28 obese children (OB) and 34 healthy control (HC), and their correlation with essential parameters associated with childhood obesity. The gene expression of IGFBP7 was higher, and the expression of IGF2 and IGFBP1 genes was lower in the OB. The expression of IGFBP6 tended to be lower in OB. IGFBP4 concentration was significantly higher, and IGFBP3 tended to be higher in the OB compared to the HC, while IGFBP1, IGFBP2, and IGFBP6 were significantly lower, and IGFBP7 tended to be lower in OB. We found numerous correlations between IGFs and IGFBP concentration and obesity metabolic parameters. IGFBP6 correlated positively with apelin, cholecystokinin, glucagone-like peptide-1, and leptin receptor. These peptides were also significantly lower in obese children in our study. The biological role of decreased levels of IGFBP6 in obese children needs further investigation.
Identifiants
pubmed: 34371941
pii: nu13072432
doi: 10.3390/nu13072432
pmc: PMC8308664
pii:
doi:
Substances chimiques
Adipokines
0
Biomarkers
0
IGF1 protein, human
0
IGF2 protein, human
0
Insulin-Like Growth Factor Binding Proteins
0
Insulin-Like Growth Factor I
67763-96-6
Insulin-Like Growth Factor II
67763-97-7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Narodowe Centrum Nauki
ID : NN 407 198737
Organisme : Jagiellonian University
ID : K/ZDS/003825
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