The Homocysteine and Metabolic Syndrome: A Mendelian Randomization Study.
homocysteine
mendelian randomization
metabolic syndrome
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
16 Jul 2021
16 Jul 2021
Historique:
received:
25
06
2021
revised:
09
07
2021
accepted:
13
07
2021
entrez:
10
8
2021
pubmed:
11
8
2021
medline:
8
9
2021
Statut:
epublish
Résumé
Homocysteine (Hcy) is well known to be increased in the metabolic syndrome (MetS) incidence. However, it remains unclear whether the relationship is causal or not. Recently, Mendelian Randomization (MR) has been popularly used to assess the causal influence. In this study, we adopted MR to investigate the causal influence of Hcy on MetS in adults using three independent cohorts. We considered one-sample MR and two-sample MR. We analyzed one-sample MR in 5902 individuals (2090 MetS cases and 3812 controls) from the KARE and two-sample MR from the HEXA (676 cases and 3017 controls) and CAVAS (1052 cases and 764 controls) datasets to evaluate whether genetically increased Hcy level influences the risk of MetS. In observation studies, the odds of MetS increased with higher Hcy concentrations (odds ratio (OR) 1.17, 95%CI 1.12-1.22,
Identifiants
pubmed: 34371949
pii: nu13072440
doi: 10.3390/nu13072440
pmc: PMC8308555
pii:
doi:
Substances chimiques
Homocysteine
0LVT1QZ0BA
MTHFR protein, human
EC 1.5.1.20
Methylenetetrahydrofolate Reductase (NADPH2)
EC 1.5.1.20
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Science, ICT and Future Planning
ID : 2013M3A9C4078158
Références
BMC Genomics. 2013 Dec 10;14:867
pubmed: 24320691
BMJ. 2018 Jul 12;362:k601
pubmed: 30002074
PLoS One. 2014 Nov 17;9(11):e113148
pubmed: 25401978
Can J Physiol Pharmacol. 2018 Oct;96(10):991-1003
pubmed: 30130426
Front Cardiovasc Med. 2015 Mar 05;2:11
pubmed: 26664883
Dig Liver Dis. 2015 Mar;47(3):181-90
pubmed: 25739820
Medicine (Baltimore). 2019 Jan;98(2):e13998
pubmed: 30633186
Oxid Med Cell Longev. 2017;2017:6873197
pubmed: 28191276
Nutr J. 2013 Apr 02;12:37
pubmed: 23547829
Hormones (Athens). 2018 Sep;17(3):299-313
pubmed: 30171523
Stroke. 2017 May;48(5):1183-1190
pubmed: 28360116
Exp Mol Med. 2019 Feb 21;51(2):1-13
pubmed: 30804341
Mol Aspects Med. 2019 Oct;69:41-47
pubmed: 30710596
Zh Nevrol Psikhiatr Im S S Korsakova. 2019;119(11):133-138
pubmed: 31851185
Curr Hypertens Rep. 2018 Feb 26;20(2):12
pubmed: 29480368
Front Aging Neurosci. 2018 Oct 31;10:350
pubmed: 30429785
Nutrients. 2020 Nov 12;12(11):
pubmed: 33198396
Medicine (Baltimore). 2016 May;95(20):e3700
pubmed: 27196483
Int J Epidemiol. 2015 Apr;44(2):551-65
pubmed: 26002927
J Endocrinol Invest. 2009 May;32(5):406-10
pubmed: 19794288
Int J Epidemiol. 2017 Apr 1;46(2):e20
pubmed: 27085081
Rev Neurol (Paris). 2019 Dec;175(10):597-603
pubmed: 31543362
Sci Rep. 2020 Nov 18;10(1):20034
pubmed: 33208868
Exp Gerontol. 2016 Aug;81:83-91
pubmed: 27167582
J Hum Hypertens. 2016 Aug;30(8):508-12
pubmed: 26155996
Int J Clin Exp Med. 2015 Nov 15;8(11):21122-9
pubmed: 26885044
Sci Rep. 2018 Apr 9;8(1):5701
pubmed: 29632305
Schizophr Bull. 2014 Sep;40(5):1154-63
pubmed: 24535549
Ann Clin Lab Sci. 2009 Summer;39(3):219-32
pubmed: 19667406
Nutr J. 2019 Oct 28;18(1):61
pubmed: 31660975
BMC Med. 2019 Jul 17;17(1):135
pubmed: 31311600
Diabetol Metab Syndr. 2020 Jul 14;12:60
pubmed: 32684985
Medicine (Baltimore). 2017 Feb;96(8):e5862
pubmed: 28225483
Nutrients. 2015 Nov 17;7(11):9492-507
pubmed: 26593940
Sci Rep. 2016 Jun 01;6:27034
pubmed: 27246655
JAMA. 2000 Apr 26;283(16):2109-15
pubmed: 10791502
Behav Res Methods. 2013 Mar;45(1):75-81
pubmed: 22528958
Stroke. 2005 Feb;36(2):321-5
pubmed: 15625295
Mol Brain. 2021 Feb 9;14(1):29
pubmed: 33563321
Int J Epidemiol. 2016 Dec 1;45(6):1961-1974
pubmed: 27616674
Lancet. 2005 Dec 3;366(9501):1954-9
pubmed: 16325697
Sci Rep. 2020 Jun 24;10(1):10283
pubmed: 32581311
Chin Med J (Engl). 2017 Aug 20;130(16):1980-1986
pubmed: 28776552
Diabetes Metab Syndr. 2017 Jul - Sep;11(3):179-182
pubmed: 27600468
J Clin Med. 2019 Dec 19;9(1):
pubmed: 31861591
Cell Death Discov. 2018 Oct 22;4:50
pubmed: 30374413